Investigation of the metabolic profile of selected anticancer tyrosine kinase inhibitors by liquid chromatography mass spectroscopy / (Record no. 69372)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02617cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032142.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190102s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.03.Ph.D.2018.Mo.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Wagih Zeidan Attwa |
| 245 10 - TITLE STATEMENT | |
| Title | Investigation of the metabolic profile of selected anticancer tyrosine kinase inhibitors by liquid chromatography mass spectroscopy / |
| Statement of responsibility, etc. | Mohamed Wagih Zeidan Attwa ; Supervised Sawsan Mohamed Mohamed Amer , Hany Wagih Darwish |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحديد و توصيف نواتج الأيض معمليا لبعض المركبات المضادة للسرطان بإستخدام الكروماتوجرافيا السائلة المتصلة بمقياس الطيف الكتلى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Wagih Zeidan Attwa , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 170 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Incubation for the selected TKIs with RLMs alone or in the presence of KCN was done. Cyclic tertiary amine rings (N-methyl piperazine in PNT and MST, and N-methyl piperidine ring in VNT) were bioactivated and formed adducts with KCN. These reactive adducts may be responsible for the observed side effects of PNT and VNT in humans, and MST in animals and humans. Development of validated LC-MS/MS methods were done and applied to metabolic stability estimation. The low intrinsic clearance (3.91 and 3.0 mL/min/kg) with long in vitro t1/2 (40 min and 50 min.) of RLMs to metabolize VNT and MST, respectively suggested that VNT and MST are slowly cleared from the blood by the liver and thus considered as low extraction ratio drugs. The low intrinsic clearance of liver to metabolize VNT and MST is a specific character for the cited drugs not a general feature to similar TKIs as CLint for PNT was 15 mL/min/kg with short in vitro t1/2 of approximately 6 min. In vivo metabolism for the cited drugs were done. All the studied TKIs are partially excreted in the rat urine. Many oxidized metabolites were detected in rat urine for the cited drugs |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | In vitro metabolism |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metabolic stability |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tyrosine kinase inhibitors |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hany Wagih Darwish , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sawsan Mohamed Mohamed Amer , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.03.Ph.D.2018.Mo.I | 01010110076503000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.03.Ph.D.2018.Mo.I | 01020110076503000 | 22.09.2023 | CD - Rom | 76503.CD |