Effect of acute peritonitis on serum fibroblast growth factor 23 (FGF23) level in male albino rats with chronic kidney disease (CKD) / (Record no. 69379)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03285cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032143.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190102s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.M.Sc.2018.Ch.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Christina Sabry Yacoub |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of acute peritonitis on serum fibroblast growth factor 23 (FGF23) level in male albino rats with chronic kidney disease (CKD) / |
| Statement of responsibility, etc. | Christina Sabry Yacoub ; Supervised Hanan Abdelaziz Mubarak , Nagwa Mahmoud Ramadan , Mohammed Mahmoud Elsebaie |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الإلتهاب البريتوني الحاد علي مستوي عامل نمو الخلايا الليفية ٢٣ في مصل الدم لذكور الفئران البيضاء المصابة بالمرض الكلوي المزمن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Christina Sabry Yacoub , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 203 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Fibroblast growth factor 23(FGF23), a bone-derived hormone that regulates phosphate and vitamin D homeostasis, found to be increased during chronic inflammation of chronic kidney disease (CKD). It is thought to be a causal factor of cardiovascular complications, CKD progression and death. So, understanding the molecular mechanisms that control FGF23 is a critical to design therapy for lowering FGF23 in CKD. The aim of the present study was to explore the effect of acute inflammation on serum FGF23 in CKD, to investigate whether the expression of furin pro-protein convertase enzyme is altered by inflammation in CKD and to clarify the difference in the biological response (regarding FGF23 levels & processing) to acute inflammation versus chronic adaptation to inflammatory stimuli in CKD and to explore the interaction between FGF23, Vitamin D and inflammation. Forty male albino rats were divided into four groups, ten rats for each group, group I: control rats, group II: experimentally induced acute peritonitis, group III: experimentally induced chronic kidney disease (CKD), group IV: CKD with acute peritonitis. The serum levels of creatinine, phosphates, intact (iFGF23), vitamin D, Tumor necrosis factor alpha (TNFa) and C-reactive protein (CRP) were measured. Also, Furin mRNA was measured in femur bone tissue. Results revealed that peritonitis significantly increased serum iFGF23, TNFa and CRP levels; meanwhile, it induced significant decrease in serum vitamin D level and bone furin mRNA compared to the control group. CKD whether alone or with peritonitis significantly increased serum creatinine, phosphate, iFGF23, TNFa and CRP levels; meanwhile, they induced significant decrease in serum vitamin D level and furin mRNA compared to the control group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CKD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FGF 23 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Peritonitis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Abdelaziz Mubarak , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Mahmoud Elsebaie , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagwa Mahmoud Ramadan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.M.Sc.2018.Ch.E | 01010110076647000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.M.Sc.2018.Ch.E | 01020110076647000 | 22.09.2023 | CD - Rom | 76647.CD |