Study on the potential hepato-therapeutic effect of S-allyl cysteine against acetaminophen overdose {u2013} induced liver toxicity in rats / (Record no. 69390)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03203cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032143.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190103s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2018.Ay.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ayat Ibrahim Samra Samra |
| 245 10 - TITLE STATEMENT | |
| Title | Study on the potential hepato-therapeutic effect of S-allyl cysteine against acetaminophen overdose {u2013} induced liver toxicity in rats / |
| Statement of responsibility, etc. | Ayat Ibrahim Samra Samra ; Supervised Hanan Salah Eldin Elabhar , Muhammad Yusuf Alshorbagy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة حول العلاج الكبدي المحتمل لـ اس - الّيل سيستايين ضد أذى الكبد المحدث بجرعة زائدة من الاسيتامينوفين في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ayat Ibrahim Samra Samra , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 182 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Methods : animals were randomly allocated into five groups (6 rats in each group). Group1 (Control group): animals in this group served as normal control group and received distilled water p.o. daily for 3 days, Group2 (APAP group): animals in this group received one single dose of APAP (1gm/kg, p.o), Groups 3 & 4 (SAC 100 & 200 groups): these animals were gavaged APAP (1gm/kg) orally and after 8 hrs they received SAC (100 or 200mg/kg, i.p), as a loading dose. After 4 hrs, animals receive half the dose (50 or 100mg/kg, i.p) as a maintenance dose then every 4 hrs for 3 days in a total of 18 doses, Group5 (NAC group): the rats in this group received APAP orally (1gm/kg), then after 8 hrs, they were administrated NAC (140mg/kg, i.p) as a loading dose. This was followed by the maintenance dose (70mg/kg i.p) four hrs later; this dose was repeated every 4 hrs for 3 days (18 doses). To induce APAP intoxication, male Wistar rats were gavaged APAP to induce toxicity. Paracetamol was suspended in distilled water to prepare a 10% solution to be administered orally in a dose of 1gm/kg. Serum samples were separated for determination of N-acetyl p-benzo quinone imine (NAPQI), alanine transaminase (ALT) and aspartate transaminase (AST). Liver was dissected to determine malondialdehyde (MDA) - glutathione (GSH), as measures of oxidative stress. Interlukin-6 (IL-6) and nuclear factor kappa (NF-m) B, as pro-inflammatory mediators. Apoptosis inducing factor (AIF), apoptosis factor caspase cleaved cytokeratin 18 fragment (M-30), GSK-3Ý/Ý-catenin, p-NF-mBp65 (at ser536) and cyclin D1 as indicators/regulators of pathways responsible for necrosis, apoptosis, proliferation, and differentiation. Also, histopathological examination is estimated |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acetaminophen |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | N-acetyl cysteine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muhammad Yusuf Alshorbagy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2018.Ay.S | 01010110076504000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2018.Ay.S | 01020110076504000 | 22.09.2023 | CD - Rom | 76504.CD |