Relative telomeric length and polymorphism in telomere maintenance gene telomerase reverse transcriptase in hepatocellular carcinoma patients / (Record no. 69413)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03114cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032144.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190105s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2018.As.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Esmail Ali Nasr Eldin |
| 245 10 - TITLE STATEMENT | |
| Title | Relative telomeric length and polymorphism in telomere maintenance gene telomerase reverse transcriptase in hepatocellular carcinoma patients / |
| Statement of responsibility, etc. | Asmaa Esmail Ali Nasr Eldin ; Supervised Enas Hamdy Mahmoud , Ahmed Ameen Emara Hekel , Alaa Afif Abdelrauof |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | النسبة الطولية لتلومير وتعدد اشكال في عكس التلموريز الناسخ في الجينات في مرضي سرطان الكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Esmail Ali Nasr Eldin , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 112 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Telomere length is maintained by telomerase in 90% of human cancers,while 10% of cancers use an alternative mechanism of telomere lengthening termed (ALT).Another mechanism for Cancer cells is through activating or upregulating the normally silent human TERT gene (hTERT) that encodes telomerase Objectives:The aim of the present study wasto assess the role of telomeric length in the development of hepatocellular carcinoma(HCC) and to study the effect of 2SNPs in TERT gene rs13167280, rs2736098 on telomere length Subjects and Methods: the study was conducted on a total number of 100 patients,subdivided into two groups HCC and HCV groups.telomeric length was measured using quantitative real time PCR(sybergreen),SNP were measuring using Taqman probe on step{u2013}one real time PCRResults:We found thatthe patients with HCC had a significant short relative telomere length(RTL)with median level 0.15 compared to the median of HCV group which was 1.03 with the p-value <0.001.The performance of Relative telomere length was detected using ROC Curve. At the cut-off value of 0.7, RTL showed sensitivity 92 %, specificity 94%, diagnostic accuracy 93% and the area under the curve (AUC) were 0.917, and there was no statistical significant difference observed on comparing the two SNPs in HCC and HCV groups Conclusions: the median value of RTL in HCC patients was short compared to HCV patients, so the relative telomeric length could be used as a non invasive biomarker for HCC |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular Carcinoma, , |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Relative telomeric length |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Telomere maintenance gene |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Ameen Emara Hekel , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alaa Afif Abdelrauof , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Enas Hamdy Mahmoud , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2018.As.R | 01010110076653000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2018.As.R | 01020110076653000 | 22.09.2023 | CD - Rom | 76653.CD |