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Relative telomeric length and polymorphism in telomere maintenance gene telomerase reverse transcriptase in hepatocellular carcinoma patients / (Record no. 69413)

MARC details
000 -LEADER
fixed length control field 03114cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032144.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190105s2018 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2018.As.R
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Asmaa Esmail Ali Nasr Eldin
245 10 - TITLE STATEMENT
Title Relative telomeric length and polymorphism in telomere maintenance gene telomerase reverse transcriptase in hepatocellular carcinoma patients /
Statement of responsibility, etc. Asmaa Esmail Ali Nasr Eldin ; Supervised Enas Hamdy Mahmoud , Ahmed Ameen Emara Hekel , Alaa Afif Abdelrauof
246 15 - VARYING FORM OF TITLE
Title proper/short title النسبة الطولية لتلومير وتعدد اشكال في عكس التلموريز الناسخ في الجينات في مرضي سرطان الكبد
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Asmaa Esmail Ali Nasr Eldin ,
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 112 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Background: Telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Telomere length is maintained by telomerase in 90% of human cancers,while 10% of cancers use an alternative mechanism of telomere lengthening termed (ALT).Another mechanism for Cancer cells is through activating or upregulating the normally silent human TERT gene (hTERT) that encodes telomerase Objectives:The aim of the present study wasto assess the role of telomeric length in the development of hepatocellular carcinoma(HCC) and to study the effect of 2SNPs in TERT gene rs13167280, rs2736098 on telomere length Subjects and Methods: the study was conducted on a total number of 100 patients,subdivided into two groups HCC and HCV groups.telomeric length was measured using quantitative real time PCR(sybergreen),SNP were measuring using Taqman probe on step{u2013}one real time PCRResults:We found thatthe patients with HCC had a significant short relative telomere length(RTL)with median level 0.15 compared to the median of HCV group which was 1.03 with the p-value <0.001.The performance of Relative telomere length was detected using ROC Curve. At the cut-off value of 0.7, RTL showed sensitivity 92 %, specificity 94%, diagnostic accuracy 93% and the area under the curve (AUC) were 0.917, and there was no statistical significant difference observed on comparing the two SNPs in HCC and HCV groups Conclusions: the median value of RTL in HCC patients was short compared to HCV patients, so the relative telomeric length could be used as a non invasive biomarker for HCC
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Hepatocellular Carcinoma, ,
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Relative telomeric length
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Telomere maintenance gene
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Ahmed Ameen Emara Hekel ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Alaa Afif Abdelrauof ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Enas Hamdy Mahmoud ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2018.As.R 01010110076653000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2018.As.R 01020110076653000 22.09.2023 CD - Rom 76653.CD