MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03001cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190109s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.33.Ph.D.2018.Mo.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Saad Eldin Ibrahim Elneklawi |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Impact of IL28B gene polymorphism on the outcome of living donor liver transplantation / |
| Statement of responsibility, etc. |
Mohamed Saad Eldin Ibrahim Elneklawi ; Supervised Ayman Yosry Abdelrehim , Mohamad Saeed Abdelaziz , Olfat Gamil Shaker |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير تحور جين الانترلوكين 28 بى على نتائج زراعة الكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mohamed Saad Eldin Ibrahim Elneklawi , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
132 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background & Aim : Recent studies have described a major impact of the IL28B gene polymorphism on the natural course and outcome of antiviral therapy in chronic hepatitis C. Our study aims to investigate the impact of IL28B of donors and recipients on the outcome of liver transplantation due to end stage HCV related liver disease, and the impact of IL28B genotypes on the response to treatment with INF based therapy or DAA.Methods: Donor and recipient IL28B rs12979860C>T single nucleotide polymorphisms (SNPs) were determined in 24 patients who had undergone LT for HCV-induced end stage liver disease and received regular follow up evaluations for two years post liver transplantation, 10 of whom were treated with pegylated interferon-a (PEG-IFN-a) and ribavirin, and 14 were treated with DAA. IL28B genetic polymorphisms were correlated with the outcome of liver transplantation and treatment response of recurrent hepatitis C.Results: We found that the CC genotype frequency was reduced among patients with HCV related end stage liver disease while, in contrast, the frequency of CT & TT increased. We also found that the donor rs12979860 CC genotype was strongly associated with the success of PEG-IFN-Ü and ribavirin treatment of recurrent hepatitis C. No association was noted between IL 28B polymorphism and fibrosis progression or patient and graft survival, and as well as liver outcomes. No impact of IL 28B polymorphism on the response to anti viral treatment (AVT) by direct acting antiviral (DAA) agents, as all different IL 28B genotypes and different recipient/donor patterns eventually achieved SVR even in cases with two unfavorable non-CC genotypes in both recipients and donors |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
IL28B |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Living donor liver transplantation |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Tropical Medicine |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ayman Yosry Abdelrehim , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamad Saeed Abdelaziz , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Olfat Gamil Shaker , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
