Enhancement of glaucoma treatment using liposome encapsulated eye drops / (Record no. 69469)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02762cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190109s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.04.M.Sc.2017.En.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Engy Abdelmalek Saed Saad |
| 245 10 - TITLE STATEMENT | |
| Title | Enhancement of glaucoma treatment using liposome encapsulated eye drops / |
| Statement of responsibility, etc. | Engy Abdelmalek Saed Saad ; Supervised Mohamed Hassanin Gaber , Neveen Moustafa Sabra , Heba Mohamed Fahmy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحسين علاج المياه الزرقاء باستخدام قطرات العين المتحوصلة داخل الليبوزومات |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Engy Abdelmalek Saed Saad , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 132 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Glaucoma is an optic neuropathy disease that is considered to be the second leading cause of blindness worldwide. Elevation of the intraocular pressure (IOP) due to increased resistance to aqueous humor outflow is recognized as a major risk factor for the development of glaucoma. Oxidative stress due to reactive oxygen species can also cause an increase in the IOP. Prostaglandin analogs like Latanoprost (LAT) are commonly used to reduce the IOP. Thymoquinone (TQ), a major bioactive ingredient of Nigella sativa, is used in traditional medicine as a part of the treatment of hypertension. The aim of this study was to develop novel liposome formulations for the ocular delivery of TQ, LAT and a mixture of them to investigate their IOP lowering effects in glaucoma-induced rabbits.Lip (LAT+TQ) and Lip (LAT) were the most effective tested formulations which provided in vivo sustained drug delivery and resulted in the maximum IOP lowering capability up to 84 hrs relative to other tested formulations. Moreover, the present work revealed the role of Thymoquinone (TQ) as a promising drug that assists in the amelioration of the retinal damage and the inflammatory responses resulting from glaucoma induction in rabbits besides its IOP lowering effect (even if it is not combined with other IOP reducing agents). It is worth to mention here that none of the prepared liposome formulations succeeded to improve the glaucoma-induced oxidative stress damage |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glaucoma treatment |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Latanoprost (LAT) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liposome encapsulated eye |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Mohamed Fahmy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Hassanin Gaber , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Neveen Moustafa Sabra , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.04.M.Sc.2017.En.E | 01010110076741000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.04.M.Sc.2017.En.E | 01020110076741000 | 22.09.2023 | CD - Rom | 76741.CD |