The possible modulatory role of an angiotensin metabolite in a Parkinson model in rats / (Record no. 69485)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02662cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032146.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190110s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2018.Mo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Adel Mohamed Elzuhary Abdelhamed Rabie |
| 245 14 - TITLE STATEMENT | |
| Title | The possible modulatory role of an angiotensin metabolite in a Parkinson model in rats / |
| Statement of responsibility, etc. | Mostafa Adel Mohamed Elzuhary Abdelhamed Rabie ; Supervised Dalaal Moustafa Abdallah , Hanan Salah Eldin Elabhar , Noha Nagah Nassar |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المعدل المحتمل لأحد المنتجات الايضية للانجيوتنسن في نموذج الشلل الرعاش بالجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mostafa Adel Mohamed Elzuhary Abdelhamed Rabie , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 172 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | MAS receptor (MASR), expressed in several brain areas, conferred neuroprotection against neurodegenerative disorders when activated by angiotensin (Ang) 1-7; however, its role in Parkinson{u2019}s disease (PD) remains elusive. Intra-striatal post-administration of Ang 1-7 using a 6-hydroxydopamine (OHDA) PD model improved motor performance and muscle coordination. Ang 1-7 also enhanced substantia nigral tyrosine hydroxylase (TH) immunoreactivity and striatal dopamine content indicating the preservation of the dopaminergic neurons. On the molecular level, Ang 1-7 increased striatal STAT-3 and SOCS3 and MASR mRNA with the upsurge in its downstream targets (p-PI3K/p-Akt/p-CREB/BDNF) to phosphorylate TrKB. This effect extended to inhibit the striatal expression of Ang II type-1 receptor (AT-1R), RAGE, and HMGB-1, in addition to reduction in PARP-1. Ang 1-7 was also able to decrease p-MAPK p38/NF-mB p65/TNF-Ü, as well as NADPH oxidase (Nox) and lipid peroxidation to level the inflammatory and oxidative stress events off. The Ang 1-7-mediated activation of MASR cue and the suppression of the AT-1R cascade were partially reversed by the intrastartial injection of A 779, a MASR antagonist |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | A 779 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Dopamine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | NADPH oxidase |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal Moustafa Abdallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Nagah Nassar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2018.Mo.P | 01010110076514000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2018.Mo.P | 01020110076514000 | 22.09.2023 | CD - Rom | 76514.CD |