Accuracy of Ý-catenin and PHOX2B in detection of bone marrow metastasis in neuroblastoma / (Record no. 69510)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02575cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032147.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190112s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2018.Sa.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Samar Sami Elshazly |
| 245 10 - TITLE STATEMENT | |
| Title | Accuracy of Ý-catenin and PHOX2B in detection of bone marrow metastasis in neuroblastoma / |
| Statement of responsibility, etc. | Samar Sami Elshazly ; Supervised Nahed Abdelwahab , Emad Nabil Ebeid , Maha Abdelhamid |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى اكتشاف انتشار مرض ورم الغدد العصبية للنخاع العظمى Ý-catenin وال PHOX2B دقه ال |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Samar Sami Elshazly , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 163 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Neuroblastoma is a pediatric cancer originating from neural crest-derived from sympatho-adrenal progenitors (Coulon et al., 2011). The identification of metastatic tumor in patients diag»nosed with neuroblastoma is a critical component of accurate staging and disease surveillance (Krishnan et al., 2009). Beta-catenin, is involved in regulation and coordination of cell-cell adhesion and gene transcription (MacDonald et al., 2009). PHOX2B has growth inhibitory effects, as its over expression promotes cell cycle exit and inhibits the proliferation of cultured sympathetic neurons (Pei, et al., 2013). Aim of the study. Evaluate accuracy of Beta-catenin and PHOX2B in detection of bone marrow metastasis in neuroblastoma compared to routine morphological examination and IHC techniques using synaptophysin and NSE. Clarify their association with the clinical parameters and the response to treatment of patients. Patient and method: The current study was carried out on 52 newly diagnosed neuroblastoma pediatric patients, along with 12 age and sex matched apparently healthy normal controls. Ý-catenin positivity on BMB using IHC techniques and PHOX2B expression using quantitative (RT-PCR) were detected in both patients and controls |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Beta catenin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neuroblastoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PHOX2B |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Emad Nabil Ebeid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Abdelhamid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nahed Abdelwahab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2018.Sa.A | 01010110076795000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2018.Sa.A | 01020110076795000 | 22.09.2023 | CD - Rom | 76795.CD |