MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02684cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190114s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.Ph.D.2018.Kh.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Khaled Ibrahim Elrefaai |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Formulation and optimization of oral drug used for erectile dysfunction / |
| Statement of responsibility, etc. |
Khaled Ibrahim Elrefaai ; Supervised Mohamed Ahmed Elnabarawi , Mahmoud Hassan Teaima |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
صياغة وتعظيم لعقارعن طريق الفم لعلاج ضعف الإنتصاب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Khaled Ibrahim Elrefaai , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
287 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Vardenafil Hydrochloride (VH) oral disintegrating tablets (ODTs) and Fast Dissolving Films (FDFS) have been prepared. Dapoxetine Hydrochloride (DH) and Caffeine was added to the best selected formula of the prepared SC ODTs to treat premature ejaculation and maintain normal blood pressure and prevent its decrease caused by administration of VH. The physicopharmaceutical properties as well as the dissolution behavior of the all the prepared (ODTs) and (FDFS) formulae were evaluated. Moreover, VH, DH and Caffeine bioavailability in human volunteers from the prepared (ODTs) and (FDFS) was compared to that of the market product oral tablet (Levitra® and Priligy®). The effect of addition of caffeine to the best selected formula of VH ODTs and unmedicated FDFs on the blood pressure of human volunteers was also monitored. Preparation of ODTs and FDFs enhanced the dissolution rate and extent of VH, DH and Caffeine with 100 % of drug being dissolved after 15 minutes. Moreover, the in vivo study showed that the bioavailability of VH in ODTs FDFs was higher than that of commercial oral product (Levitra®), with relative bioavailability values of 100.9 % and 116% respectively compared to the commercial oral product (Levitra®). Addition of caffeine to the best selected formula of VH ODTs and unmedicated FDFs inhibit severe decrease in the blood pressure which caused by administration of the best selected formula of VH ODTs, FDFs and commercial oral product (Levitra®) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Erectile dysfunction |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Oral disintegrating tablet |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Vardenafil Hydrochloride |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mahmoud Hassan Teaima , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Ahmed Elnabarawi , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
