Analytical and pharmacokinetic studies of some pharmacologically active nitrogenous compounds / (Record no. 69670)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03156cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032152.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190121s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2018.Sa.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sally Tarek Mahmoud Abdelhameed |
| 245 10 - TITLE STATEMENT | |
| Title | Analytical and pharmacokinetic studies of some pharmacologically active nitrogenous compounds / |
| Statement of responsibility, etc. | Sally Tarek Mahmoud Abdelhameed ; Supervised Bahia Abbas Moussa , Hanaa Abdel Monem Hashem , Marianne Alphonse Mahrouse |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تحليلية ودراسة حركية الدواء لبعض المركبات النيتروجينية ذات الفاعلية الفارماكولوجية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sally Tarek Mahmoud Abdelhameed , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 168 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This thesis is concerned with the development of simple and accurate methods for the determination of a newly approved drug combination (Sacubitril and Valsartan) for the treatment of heart failure in commercially used formulation either alone or in the presence of their degradation products and/or their related impurities or in biological fluids, and the evaluation of certain drug-drug interactions and drug-food interactions of this newly approved combination (Sacubitril and Valsartan). Application of experimental design approach in optimization of RP-HPLC method for simultaneous determination of Sacubitril and Valsartan in presence of their degradation productsand forced degradation study of Sacubitril under different stress conditions was proposed. Application of RP-HPLC method to a study of the assessment of drug-drug interaction potential of concomitant use of Sacubitril/Valsartan on the pharmacokinetic of Rosuvastatin in ratsthrough in-vivo study. In addition, assessment of the influence of grapefruit juice on the activation of the prodrug Sacubitril was evaluated using rat liver S9 fraction in in-vitro study. HPLC-MS/MS method was proposed for separation and quantitation of Sacubitril and Valsartan in human plasma with some of the co-administered drugs (Chlorthalidone, Esomeprazole and Nebivolol) that are usually prescribed together according to the guidelines of heart failure treatment. Moreover, derivative ratio spectrofluorimetric method was proposed as rapid and simple methodology for resolving spectral overlap displayed by Sacubitril and Valsartan spectra.The proposed methods were validated and statistically compared with reference methods where no significant difference was found |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Degradation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Experimental design |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HPLC |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bahia Abbas Moussa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanaa Abdel Monem Hashem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marianne Alphonse Mahrouse , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2018.Sa.A | 01010110076868000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2018.Sa.A | 01020110076868000 | 22.09.2023 | CD - Rom | 76868.CD |