Evaluation of the potential mechanisms involved in the renal therapeutic effect of vitamin D and/ or pioglitazone on ischemia reperfusion injury induced in male rats / (Record no. 69739)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03255cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032154.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190126s2018 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2018.Ra.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rabab Mohamed Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the potential mechanisms involved in the renal therapeutic effect of vitamin D and/ or pioglitazone on ischemia reperfusion injury induced in male rats / |
| Statement of responsibility, etc. | Rabab Mohamed Ali ; Supervised Hanan Salah Eldin Elabhar , Dalaal Mostafa Abdallah Muhammad , Yusuf Alshorbagy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم الآليات المحتملة لعلاج الكلى بـ{uئآ٦ؤ}ـيتامين د مع أو بدون عقار البيوجليتازون في ذكور الجرذان المعرضة لنقص الدم وإعادة التروية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rabab Mohamed Ali , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 148 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Renal ischemia-reperfusion injury (I/RI) remains a critical clinical situation. Several evidence revealed the potential reno-protective effects of Vitamin D and/or pioglitazone, on renal I/RI. This study addresses the possible involvement of the Wnt4/Ý-catenin signaling, p-S536NF-mBp65, PPARÞ, Ang II/TGF-Ý, and ACE2 as potential effectors to vitamin D and pioglitazone-mediated renoprotective effects . Two sets of Sprague-Dawley rats (n=30 rat each), were randomized into sham, I/R, Vit D "alfacalcidol" (5 ng/kg/day), pioglitazone (5 mg/kg/day), and Vit D + pioglitazone groups. In all groups renal biochemical parameters, as well as inflammatory and structural profiles were assessed, besides the expression/contents of Wnt4/Ý-catenin and pS536-NF-mBp65. All treatments started 7 days before I/RI and animals were killed 24 h after I/RI in the first set, while those in the 2nd set continued their treatments for 14 days. After 24 h, all pre-treatments impeded theI/R effect on neutrophils recruitment, p-S536NF-mBp65, IL-18, NGAL, caspase-3, AngII, ACE-2, PPARÞ and TGF-Ý, besides the expression of Wnt4 and ACE-2 with notable reflection on histological changes. Two weeks after I/RI, except a marked up regulation in Wnt4 expression and a striking elevation in the Ý-catenin content, the magnitude of the injurious events was relatively less pronounced, an effect that was mostly augmented by the different treatments. The current study pledges a promising and novel reno-protective role of the administration of Vit D and pioglitazone entailing a potential involvement of ICAM-1, MPO, NF-mB, Ang II, ACE2, TGFÝ, and a modulation of Wnt4/Ý-catenin pathway |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ischemia/reperfusion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vit D; pioglitazone |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Wnt4/Ý-catenin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal Mostafa Abdallah Muhammad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yusuf Alshorbagy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2018.Ra.E | 01010110076984000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2018.Ra.E | 01020110076984000 | 22.09.2023 | CD - Rom | 76984.CD |