MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02894cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190127s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.05.M.Sc.2018.Me.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mennatullah Nagy Abdelhamed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis of certain 1,3,5-trisubstituted pyrazole derivatives of potential anticancer activity / |
| Statement of responsibility, etc. |
Mennatullah Nagy Abdelhamed ; Supervised Safinaz Elsayed Abbas , Riham François George , Eman Mohamed Samir |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تشييد بعض مشتقات 1, 3, 5- ثلاثي مستبدلات البيرازول المتوقع لها فاعلية مضادة للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mennatullah Nagy Abdelhamed , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
111 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Cancer is the second cause of mortality after cardiac diseases in the world. It is continuing to act as a major problem of health in both developing and developed countries. Therefore, there is a continuous need to search of new anticancer hits that inhibit different targets leading to more efficacies and less side effects compared to the traditional agents.Literature cited that pyrazoleand pyrazoline derivatives display a therapeutic activity as anticancer agents against breast, colon, lung, liver, cervical cancer by acting on variable targets through different mechanisms of action.Accordingly, the present study is concerned with the synthesis of new derivatives belonging to 1,3,5-trisubstituted pyrazole/pyrazolinesVIa,b,VII, VIIIand substituted thiazolylpyrazolinesXa-d, XIIa-c,XIVa-d. This is achieved via two intermediates, namely: 2-chloro-6-methoxy quinolin-3-yl chalcone IV and 5-(2-chloro-6-methoxyquinolin-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide VIb. The newly synthesized compoundswere evaluated for their in vitro cytotoxicity against three human cancer cell lines namely: MCF7 (breast), Hela (cervical), DLD1 (colon) in addition to normal fibroblast cell (WI38) relative to CHS 828 as a reference compound. Compounds eliciting superior anticancer activity were screened their EGFR inhibitory activity compared to gefitinib.Moreover a molecular docking study was performed on compounds exhibiting significant EGFR inhibitory activity to find their binding mode in the active site of the enzyme |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
1,3,5-trisubstituted pyrazole |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Anticancer |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cancer |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Eman Mohamed Samir , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Riham François George , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Safinaz Elsayed Abbas , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
