MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02304cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190218s2018 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.05.M.Sc.2018.Me.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mennat Allah Mohammed Mahmoud Elsawah |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis and biological evaluation of some novel coumarin derivatives of expected cholinesterase inhibitory activity / |
| Statement of responsibility, etc. |
Mennat Allah Mohammed Mahmoud Elsawah ; Supervised Kamilia Mahmoud Amin , Yassin Mohammed Nissan , Walaa Ramadan Mahmoud |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التشييد و التقييم الحيوى لبعض مشتقات الكومارين الجديدة المتوقع لها نشاط مثبط لإنزيم الكولين إستريز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mennat Allah Mohammed Mahmoud Elsawah , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
161 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Coumarin is an interesting bioactive scaffold eliciting a wide range of biological activities including anticancer, antibacterial, anti-inflammatory, antihypertensive and anticonvulsant activity. Herein, we highlighted on the acetylcholinesterase inhibitory activity of the coumarin nucleus notably 6-aminocoumarin derivatives which were reported to possess acetylcholinesterase inhibitory activity and many of them are in clinical trials. In this work, six series of 6-aminocoumarin-based compounds were synthesized. The target compounds featured a variety of bioactive chemical fragments of CNS action. Acetylcholinesterase inhibitory activity study was performed for all synthesized compounds. Furthermore, in silico studies were performed on the synthesized compounds which included molecular docking study at the active site of AChE enzyme as well as prediction of their pharmacokinetic parameters |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Acetylcholinesterase |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Alzehimer{u2019}s |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Coumarin |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kamilia Mahmoud Amin , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Walaa Ramadan Mahmoud , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yassin Mohammed Nissan , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
