Clinical significance of Beclin-1, Bcl-2, Bcl-xL, Bad and Bax in the whole spectrum of HCV-related chronic liver diseases / (Record no. 70277)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03147cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032209.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190218s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.01.M.Sc.2018.Mu.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mustafa Ali Ahmed Elshobaky |
| 245 10 - TITLE STATEMENT | |
| Title | Clinical significance of Beclin-1, Bcl-2, Bcl-xL, Bad and Bax in the whole spectrum of HCV-related chronic liver diseases / |
| Statement of responsibility, etc. | Mustafa Ali Ahmed Elshobaky ; Supervised Tarek Mohamed Kamal Motawi , Eman Abdelalleem Amer , Dalia Abdelhameed Omran |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | على امراض الكبد المزمنة المتعلقة بفيروس التهاب الكبد الوبائى ج Beclin-1 و Bcl-2 و Bcl-xL و Bad و Bax التأثير الاكلينيكى لجينات |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mustafa Ali Ahmed Elshobaky , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 110 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Autophagy plays an important role in the pathogenesis of many diseases such as liver diseases. However, the exact part it plays remains unclear. We investigated the mRNA expression levels of Beclin-1 (autophagic component), proapoptotic components (Bad, Bax), and antiapoptotic components (Bcl-2, Bcl-xL) in venous blood samples drawn from hepatitis C virus (HCV) genotype 4-infected patients with or without hepatocellular carcinoma (HCC). The study included 30 healthy people (control group), 64 chronic hepatitis C patients in early hepatic fibrosis stages [grades 0 and 1 fibrosis] (F0-1 group), 36 chronic hepatitis C patients in late hepatic fibrosis stages [grades 2 and 3 fibrosis] (F2-3 group), and 47 chronic hepatitis C patients with HCC (HCC group). The F0-1 Group and F2-3 Group were called chronic hepatitis group. qPCR was used to measure mRNA expression levels of the different parameters in the samples. Beclin-1, Bad, and Bax mRNA expression levels were significantly higher in the F0-1 group than in the F2-3 and control groups (P<0.01), while Bcl-2 and Bcl-xL mRNA expression levels were significantly lower (P<0.01). Moreover, Beclin-1, and Bad mRNA expression levels were significantly lower in the HCC group than in the chronic hepatitis and control groups (P<0.01), while Bcl-2, and Bcl-xL mRNA expression levels were significantly higher (P=0.04; P<0.01 respectively). These results demonstrate that autophagy-related genes play an important role as diagnostic and prognostic factors in both the early stages of hepatic fibrosis in HCV genotype 4-infected patients, and chronic hepatitis C patients who are susceptible to HCC development |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Autophagy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatic fibrosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C virus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Abdelhameed Omran , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Abdel alleem Amer , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek Mohamed Kamal Motawi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.01.M.Sc.2018.Mu.C | 01010110077231000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.01.M.Sc.2018.Mu.C | 01020110077231000 | 22.09.2023 | CD - Rom | 77231.CD |