Study of the possible protective effects of apigenin and plumbagin in hepatic ischemia-reperfusion injury in rats / (Record no. 70283)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03086cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032209.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190218s2018 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2018.Ay.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aya Mohamed Zaki Eid |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the possible protective effects of apigenin and plumbagin in hepatic ischemia-reperfusion injury in rats / |
| Statement of responsibility, etc. | Aya Mohamed Zaki Eid ; Supervised Hala F. Zaki , Rania M. Abdelsalam , Dalia M. Eltanbouly |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثير الوقائى المحتمل لكل من ابيجينين و بلومباجين منفردين فى فقر الدم الموضعى و اعادة التروية فى كبد الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Aya Mohamed Zaki Eid , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 168 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Ischemia-reperfusion (I/R) injury is a pathological process which magnifies with the ensuing inflammatory response and endures with the increase of oxidants especially during reperfusion. The present study was conducted to assess the possible modulatory effects of two biologically active constituents of plant origin named apigenin and plumbagin, where the former is the active constituent extracted from the roots of traditional medicinal plant Plumbago zeylanica L and the latter is a flavonoid that exists abundantly in numerous herbs and vegetables, including chamomile, thyme, parsley and broccoli., on the dire role of high mobility group box (HMGB1) as well as the associated inflammation, oxidative stress and apoptotic cell death following hepatic I/R. Six groups of rats were included: sham operated, sham operated treated with apigenin, sham operated treated with plumbagin, I/R (30 min ischemia and 1 h reperfusion) , I/R treated with apigenin and I/R treated with plumbagin. Pretreatment with apigenin and plumbagin markedly improved hepatic function and histology, as indicated by reduced transaminase levels, lactate dehydrogenase activity and ameliorated tissue pathological changes. They significantly reduced high mobility group box 1 (HMGB1) expression and subsequently suppressed inflammatory cascades, as liver NF-mB and TNF-Ü as well as MPO activity. Both were capable of interrupting ROS-HMGB1loop as evident by restored liver GSH, decreased liver lipoperoxidation, and enhanced glutathione peroxidase (GPx) activity. Simultaneously, apoptosis was significantly ameliorated by increasing the Bcl-2/Bax ratio |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apigenin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ischemia-reperfusion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liver |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Moustafa Eltanbouly, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Mohsen Abdelsalam , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2018.Ay.S | 01010110077232000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2018.Ay.S | 01020110077232000 | 22.09.2023 | CD - Rom | 77232.CD |