MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02767cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190218s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2018.Ya.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yasmine Elazab Abdellatif |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A pharmaceutical study on smoking cessation drug for topical application / |
| Statement of responsibility, etc. |
Yasmine Elazab Abdellatif ; Supervised Hanan Ellithy , Emad Basalious , Amal Youssef Mohamed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة صيدلية على عقار لوقف التدخين للاستعمال الموضعى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Yasmine Elazab Abdellatif , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
153 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Nicotine (NI), the main active component in cigarettes is a water and lipid soluble drug which is absorbed via respiratory tissues, skin, and gastrointestinal tract (GIT). It undergoes extensive liver metabolism by cytochome P450 enzymes. Smokers become dependent on as Nicotine (NI) raises the levels of dopamine and norepinephine in the brain and when people stop smoking, NI withdrawal syndrome occurs such as craving for tobacco, irritability, nervousness, concentration difficulty, impatience, insomnia and increased appetite. Recently, increasing interest has been given to the use of NI or its salts like Nicotine bitartrate (NBT) in different dosage forms (gum, inhalers, buccal film and transdermal patch) as Nicotine replacement therapy for smoking cessation. Transdermal drug delivery of the Nicotine is the most suitable route for Nicotine replacement therapy (NRT) to avoid the first pass effect, but still the skin considers as big barrier for permeation of Nicotine and reaching to general circulation. Based on these considerations, the current work has aimed to develop different delivery systems of NBT as substitution of Nicotine for topical application. The improvement of skin permeation of NBT was performed by using sucrose esters (SE) as permeation enhancer in the matrix patch system and in combination with glycerin in the NBT loaded glycerosomal systems. In this way, easy, painless and continuous NBT delivery through the skin into the blood stream could be ensured producing constant plasma concentration over a long period |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nicotine (NI) |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Smoking cessation drug |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Topical application |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Amal Youssef Mohamed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Emad Basalious , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hanan Ellithy , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
