Study on the effect of saxagliptin on renal injury induced by ischemia/reperfusion in rats / (Record no. 70344)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03314cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032211.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190219s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2018.Na.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nada Muhammad Kamel Muhammad |
| 245 10 - TITLE STATEMENT | |
| Title | Study on the effect of saxagliptin on renal injury induced by ischemia/reperfusion in rats / |
| Statement of responsibility, etc. | Nada Muhammad Kamel Muhammad ; Supervised Dalaal M. Abdallah , Hanan S. Elabhar , May Ahmad Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تأثير الساكساجليبتين فى الإعتلال الكلوى المحدث عن طريق إعاقة تدفق الدم إلى الكلى ثم إعادة التروية فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nada Muhammad Kamel Muhammad , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 118 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Saxagliptin, a dipeptidyl peptidase (DPP)-4 inhibitor, is currently used in type 2 diabetes mellitus; however, its potential role against the renal ischemia/reperfusion (I/R) insult has not been elucidated. Using the renal I/R model in Wistar rats, saxagliptin (10 and 30 mg/kg) operated through different axes to enhance renal perfusion, it increased the renal kidney injury molecule-1/p-STAT3 (Tyr705)/hypoxia inducible factor-1Ü/vascular endothelial growth factor (VEGF) pathway to enhance angiogenesis. Additionally, by inhibiting DPP-4, saxagliptin spared the stromal cell derived factor-1Ü and increased its receptor, the chemokine receptor (CXCR) 4, to trigger vasculogenesis by enhancing the migration of endothelial progenitor cells (EPCs), designated by the elevated immunoreactive CD133+ cells. The gliptin also saved glucagon like peptide-1, with the subsequent increase in cAMP that positively influenced VEGF and CXCR4. Another pathway stimulated by saxagliptin was the atrial natriuretic peptide/endothelial nitric oxide synthase that increased nitric oxide to provoke angiogenesis and renal vasodilation. These interrelated molecules improved kidney function of rats subjected to acute renal I/R, as evidenced by the decreased serum creatinine, blood urea nitrogen, and cystatin C, increased serum albumin, and improved the histological structure. Additionally, saxaglipitin suppressed the renal phosphor-serine 536 nuclear factor-mB p65, monocyte chemoattractant protein-1, myeloperoxidase, malondialdehyde, and tumor necrosis factor-Ü, while boosted glutathione. Accordingly, saxagliptin, dose dependently, ameliorated I/R-induced renal damage via its anti-inflammatory and antioxidant activities, besides the enhancement of neovascularization through improving tissue perfusion and homing of bone marrow derived EPCs to intercede repair processes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GLP-1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Kim-1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Saxagliptin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal Moustafa Abdallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Hamdy Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | May Ahmad Galal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2018.Na.S | 01010110077243000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2018.Na.S | 01020110077243000 | 22.09.2023 | CD - Rom | 77243.CD |