A pilot study of different morphological features in myeloproliferative neoplasms with calreticulin mutations / (Record no. 70590)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02846cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032219.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190302s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2018.Sh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shimaa Ahmed Mosaad Basha |
| 245 12 - TITLE STATEMENT | |
| Title | A pilot study of different morphological features in myeloproliferative neoplasms with calreticulin mutations / |
| Statement of responsibility, etc. | Shimaa Ahmed Mosaad Basha ; Supervised Sherif Naseh Amin , Yasser Hassan Elnahass , Fatma Elrefaey |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مبدئية صغيرة النطاق للصفات المورفولوجية المختلفة في الأورام الميلودية التكاثرية ذات الطفرة الجينية في الكالريتكولين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shimaa Ahmed Mosaad Basha , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 109 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Back ground Philadelphia chromosome{u2013}negative myeloproliferative neoplasms constitute a heterogeneous group of hematopoietic disorders manifested by a variety of morphologic changes in the bone marrow (BM).Calreticulin(CALR) is a multifunctional protein that binds Ca2+ions (a second messenger in signal transduction), rendering it inactive.The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal.CALR is located in storage compartments associated with the endoplasmic reticulum. Aim of the work: The aim of this study is to describe and correlate the morphologic features ofmyeloproliferative neoplasms(MPNs) especially ET and PMF with CALR mutations. Patients and Methods: The study was conducted on 68 MPNs patients;41/68 ET ,24/68 PMF and 3/68 post ET-MF.CALR Mutations By High ReslutionMelting(HRM) Analysis and Bone marrow trephine biopsy were done. Results : CALR-mut ET patients were more likely to show dense clustering of megakaryocytes compared to CALR-wt patients 8/10 (80%) vs 13/31 (41.9%) (p = 0.036).CALR-mut PMF showed megakaryocytes that more often exhibited nuclear hyperchromasia compared to CALR-wt PMF 3 / 4(75%) cases vs 11 / 20(55%) cases ( P = .0615). All post ET-MF patients showed variable megakaryocyte morphology. 3/4(75%) were JAK 2 positive .variable morphology included more abnormal bizzare ,hypolobated morphology |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CALR |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MPL |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MPN |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Elrefaey , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherif Naseh Amin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yasser Hassan Elnahass , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2018.Sh.P | 01010110077282000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2018.Sh.P | 01020110077282000 | 22.09.2023 | CD - Rom | 77282.CD |