Comparative study between sitagliptin and donepezil on experimentally-induced alzheimer{u2019}s disease in rats / (Record no. 70806)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02988cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032225.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190313s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.Ph.D.2018.Mo.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Hassan Gad |
| 245 10 - TITLE STATEMENT | |
| Title | Comparative study between sitagliptin and donepezil on experimentally-induced alzheimer{u2019}s disease in rats / |
| Statement of responsibility, etc. | Mohammed Hassan Gad ; Supervised Amal Anwar Mishriki , Eman Abdelmonem Abdelrasheed , Afaf Sayed Osman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | مقارنة بين السيتاجليبتين والدونيبيزيل في مرض الزهايمر المحدث تجريبيا في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohammed Hassan Gad , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 141 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: The aim of this study is to investigate the possible role of sitagliptin on improving memory defects in Alzheimer's disease in rats.This was performed by comparing sitagliptin withdonepezil in both diabetic and non-diabetic models of Alzheimer'sdisease.Material and methods: Eightyadult female albino rats, matched for age and weight (between 150 and 230 g) were used for the experiment. The rats were divided into main 4 groups:Group (1) untreated rats were left to the end of the experiment.Group (2) Sitagliptin 10 mg/kg was given orally by gavage. Group (3) Alzheimer model was done by intrapertonial injection of aluminum chloride that was dissolved in water and injected to rats in a dose of 4.2mg/kg for 28 days and subdivided into 3 groups.Group (3a) after intrapertonial injection of aluminum chloride, rats were left untreated.Group (3b) sitagliptin 10 mg/kg was given orally for 2 weeks after starting aluminum chloride injection and was used for 28 days. Group (3c) donepezil 1 mg/kg was given orally 2 weeks after starting aluminum chloride injection and was used for 28 days. Group (4) diabetes mellitus was induced by a single intraperitoneal injection of freshly dissolved streptozotocin (STZ) 60 mg/kg to 18 h fasted rats. Animals with fasting blood glucose above 200 mg/dl were included in the study as diabetics and subdivided into 3 groups.Group (4a) rats were left untreated.Group (4b) sitagliptin 10 mg/kg was given orally to diabetic rats and was used for 28 days. Group (4c) donepezil 1 mg/kg was given orally to diabetic rats and was used for 28 days |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Memory changes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Morris water maz test |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sitagliptin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Afaf Sayed Osman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Anwar Mishriki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Abdelmonem Abdelrasheed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.Ph.D.2018.Mo.C | 01010110077413000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.Ph.D.2018.Mo.C | 01020110077413000 | 22.09.2023 | CD - Rom | 77413.CD |