Evaluation of some molecular markers for early diagnosis of cardiovascular complications in cases of type 2 diabetes mellitus / (Record no. 70834)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02948cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032226.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190313s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2018.Do.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Doaa Samir Salah Eldin |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of some molecular markers for early diagnosis of cardiovascular complications in cases of type 2 diabetes mellitus / |
| Statement of responsibility, etc. | Doaa Samir Salah Eldin ; Supervised Ahmed Ibrahim Amin , Ahmed Osman Mostafa Egiza |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم بعض الدلالات الجزيئية للتشخيص المبكر لمضعافات أمراض القلب والأوعية الدموية في حالات النوع الثاني لمرض البول السكري |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Doaa Samir Salah Eldin , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 150 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Diabetes is a metabolic disease distinguished by increased glucose in the bloodstream resulted from insulin secretion defect, insulin action, or both. Type 2 diabetes mellitus (T2DM) is related to micro- and macrovascular diseases increased risk. Exact T2DM vascular damage mechanisms have not been fully settled, but reduced extracellular matrix remodeling regulations by tissue inhibitor metalloproteinase (TIMP) and matrix metalloproteinases (MMPs) may cause the vascular complications. This work investigated associations between TIMP-1 expression level, and osteopontin (OPN) concentration with diabetic cardiovascular diseases (CVD) in type 2 diabetic patients, to predict potential progression and aid in case management. These were examined on 80 individuals, divided into three groups as follows: 20 volunteer healthy control individuals, 30 diabetic patients, and 30 diabetic patients suffer from cardiovascular diseases. Full clinical investigations were carried out and the expression levels of TIMP-1 in blood samples were analyzed by real time PCR, using gene-specific primer pairs, also osteopontin concentrations had been measured by the enzyme linked immunosorbent assay (ELISA). Data were statistically analyzed; TIMP-1 expression levels, and osteopontin concentrations were significantly increased in diabetic and cardiovascular diabetic groups as compared to the control group also they were significantly increased in cardiovascular diabetic group as compared to the diabetic group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Expression level |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Molecular markers |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tissue inhibitor metalloproteinase-1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Ibrahim Amin, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Osman Mostafa Egiza , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2018.Do.E | 01010110077429000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2018.Do.E | 01020110077429000 | 22.09.2023 | CD - Rom | 77429.CD |