MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02994cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190314s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.28.M.Sc.2018.Ba.T |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Basma Sayed Atwa Mohamed Mansour |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Tumor necrosis factor induced protein 3 gene polymorphism and the susceptibility to chronic primary immune thrombocytopenia in Egyptian children / |
| Statement of responsibility, etc. |
Basma Sayed Atwa Mohamed Mansour ; Supervised Dalia Sayed Mosallam , Shahira Kamal Anis , Marwa Abdelhady Abdelsamad |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تعدد الأشكال الجينيه لعامل نخر الورم التى يسببها بروتين ٣ و علاقتها بنقص الصفائح المناعى الأولى المزمن فى الأطفال المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Basma Sayed Atwa Mohamed Mansour , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
134 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Introduction: Immune thrombocytopenia (ITP) is an autoimmune mediated heterogenous disease where both genetic and environmental factors share in its development. Tumor necrosis factor induced protein 3 gene (TNFAIP3) is a common susceptibility gene to multiple autoimmune diseases including ITP. Aim of work: To investigate the relationship between the distribution of TNFAIP3 (rs5029939: C>G) polymorphism and the susceptibility to chronic primary ITP in Egyptian children. Subjects and methods: This was a case-control study on 40 chronic ITP patient and 50 age and gender matched healthy controls. DNA samples from patients and controls were tested for TNFAIP3 rs5029939 C/G single nucleotide polymorphism (SNP) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: TNFAIP3 rs 5029939 C/G mutant heterozygous genotype was found in 22.5% and 18.5% of cases and controls respectively, while the C/C wild genotype was found in 77.5% and 82.5% of cases and controls respectively. The mutant allele G was encountered in 11.2% of chronic ITP cases group and 9% of control group. We found no statistically significant difference between the two groups as regards susceptibility to chronic ITP with p - value = 0.596, OR = 1.323, 95% CI = 0.470 {u2013} 3.723. We also found no statistically significant difference between chronic ITP patients carrying wild C/C genotype and those carrying mutant C/G genotype regarding response to treatment with p - value = 1, OR = 1.667, 95% CI = 0.165-16.810 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Chronic ITP |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Gene polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
TNFAIP3 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dalia Sayed Mosallam , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Marwa Abdelhady Abdelsamad , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shahira Kamal Anis , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
