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Design, synthesis and biological evaluation of some new furochromone and benzofuran derivatives as P38 Ü MAP kinase inhibitors / (Record no. 70913)

MARC details
000 -LEADER
fixed length control field 02413cam a2200337 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032229.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190318s2018 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.08.05.Ph.D.2018.Ay.D
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Aya Mohamed Abdelkader Serry
245 10 - TITLE STATEMENT
Title Design, synthesis and biological evaluation of some new furochromone and benzofuran derivatives as P38 Ü MAP kinase inhibitors /
Statement of responsibility, etc. Aya Mohamed Abdelkader Serry ; Supervised Kamilia Mahmoud Amin , Manal Mohamed Anwar
246 15 - VARYING FORM OF TITLE
Title proper/short title تصميم و تشييد وتقييم حيوى لبعض مشتقات الفيوروكرومون و البنزوفيوران الجديدة كمثبطات لانزيم الماب كيناز ب-38
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Aya Mohamed Abdelkader Serry ,
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 136 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry
520 ## - SUMMARY, ETC.
Summary, etc. In a search for new anticancer candidates with improved profiles and selective properties and encouraged by the marked cytotoxic activity exhibited by some natural and synthetic furochromones and benzofurans against various malignant cell types, it deemed of interest to synthesize and investigate the potential anticancer and anti-p38Ü MAPK activities of some new furochromone and benzofuran derivatives. Thus, in this study, thirty-two new furochromone derivatives and eleven new benzofuran derivatives were synthesized through simple synthetic procedures. Some of the prepared known and all of the new furochromones and eleven benzofurans were screened for their in vitro cytotoxicity and their in vitro anti- p38Ü MAPK. In addition, some representative compounds were selected for cell cycle analysis and apoptosis detection through the induction of caspases -9 and -3. Furthermore, the tested compounds were investigated for their p38Ü MAPK binding properties through molecular docking studies
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Benzofurans
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Furochromone
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term P38 MAP Kinase
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Kamilia Mahmoud Amin ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Manal Mohamed Anwar ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.08.05.Ph.D.2018.Ay.D 01010110077453000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.08.05.Ph.D.2018.Ay.D 01020110077453000 22.09.2023 CD - Rom 77453.CD