Design, synthesis and biological evaluation of some new furochromone and benzofuran derivatives as P38 Ü MAP kinase inhibitors / (Record no. 70913)
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000 -LEADER | |
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fixed length control field | 02413cam a2200337 a 4500 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | EG-GiCUC |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20250223032229.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 190318s2018 ua dh f m 000 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | EG-GiCUC |
Language of cataloging | eng |
Transcribing agency | EG-GiCUC |
041 0# - LANGUAGE CODE | |
Language code of text/sound track or separate title | eng |
049 ## - LOCAL HOLDINGS (OCLC) | |
Holding library | Deposite |
097 ## - Thesis Degree | |
Thesis Level | Ph.D |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
Classification number | Cai01.08.05.Ph.D.2018.Ay.D |
100 0# - MAIN ENTRY--PERSONAL NAME | |
Personal name | Aya Mohamed Abdelkader Serry |
245 10 - TITLE STATEMENT | |
Title | Design, synthesis and biological evaluation of some new furochromone and benzofuran derivatives as P38 Ü MAP kinase inhibitors / |
Statement of responsibility, etc. | Aya Mohamed Abdelkader Serry ; Supervised Kamilia Mahmoud Amin , Manal Mohamed Anwar |
246 15 - VARYING FORM OF TITLE | |
Title proper/short title | تصميم و تشييد وتقييم حيوى لبعض مشتقات الفيوروكرومون و البنزوفيوران الجديدة كمثبطات لانزيم الماب كيناز ب-38 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Cairo : |
Name of publisher, distributor, etc. | Aya Mohamed Abdelkader Serry , |
Date of publication, distribution, etc. | 2018 |
300 ## - PHYSICAL DESCRIPTION | |
Extent | 136 P. : |
Other physical details | charts , facsimiles ; |
Dimensions | 25cm |
502 ## - DISSERTATION NOTE | |
Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
520 ## - SUMMARY, ETC. | |
Summary, etc. | In a search for new anticancer candidates with improved profiles and selective properties and encouraged by the marked cytotoxic activity exhibited by some natural and synthetic furochromones and benzofurans against various malignant cell types, it deemed of interest to synthesize and investigate the potential anticancer and anti-p38Ü MAPK activities of some new furochromone and benzofuran derivatives. Thus, in this study, thirty-two new furochromone derivatives and eleven new benzofuran derivatives were synthesized through simple synthetic procedures. Some of the prepared known and all of the new furochromones and eleven benzofurans were screened for their in vitro cytotoxicity and their in vitro anti- p38Ü MAPK. In addition, some representative compounds were selected for cell cycle analysis and apoptosis detection through the induction of caspases -9 and -3. Furthermore, the tested compounds were investigated for their p38Ü MAPK binding properties through molecular docking studies |
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
Additional physical form available note | Issued also as CD |
653 #4 - INDEX TERM--UNCONTROLLED | |
Uncontrolled term | Benzofurans |
653 #4 - INDEX TERM--UNCONTROLLED | |
Uncontrolled term | Furochromone |
653 #4 - INDEX TERM--UNCONTROLLED | |
Uncontrolled term | P38 MAP Kinase |
700 0# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kamilia Mahmoud Amin , |
Relator term | |
700 0# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Manal Mohamed Anwar , |
Relator term | |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
Cataloger | Nazla |
Reviser | Revisor |
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
Cataloger | Shimaa |
Reviser | Cataloger |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | Dewey Decimal Classification |
Koha item type | Thesis |
Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
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Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2018.Ay.D | 01010110077453000 | 22.09.2023 | Thesis | ||
Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2018.Ay.D | 01020110077453000 | 22.09.2023 | CD - Rom | 77453.CD |