Topoisomerase ii Ü gene amplification as predictive factor for anthracycline based chemotherapy in triple negative breast cancer / (Record no. 71128)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03007cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032234.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190401s2018 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2018.Ma.T |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mahitab Ibrahim Mohammed Altohamy |
| 245 10 - TITLE STATEMENT | |
| Title | Topoisomerase ii Ü gene amplification as predictive factor for anthracycline based chemotherapy in triple negative breast cancer / |
| Statement of responsibility, etc. | Mahitab Ibrahim Mohammed Altohamy ; Supervised Mona Ali Abdelfattah Sakr , Iman loay Hussein , Hanan Ramadan Nassar |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | اختبار ايجابية جين توبوايزوميريز اثنان ألفا كعامل فى التنبؤ بالاستجابة للعلاج الكيميائى القائم على الانثراسيكلين فى حالات سرطان الثدى ثلاثى السلبية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mahitab Ibrahim Mohammed Altohamy , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 90 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Breast cancer is the most prevalent cancer and the leading cause of cancer death in female worldwide. TNBC forms 15% of breast cancer cases. It has a poor prognosis and lacks the responsiveness to hormonal and targeted therapies. Anthracyclines remain the most appropriate treatment for TNBC, but its cardiotoxicity necessitates selection of patients who will really benefit from it. From predictive factors of adjuvant anthracyclines sensitivity: Chromosome 17 CEP polysomy, TOP2A gene abnormality (deletion or amplification) and high Ki-67 proliferation index. Aim of work: To investigate TOP2A gene copy number and chromosome 17 CEP polysomy by FISH technique. Material aAnd methods: Immunohistochemistry for detection of Ki-67 LI and FISH technique for detection of TOP2A gene copy number and chromosome 17 CEP status, both were done on our study cases (50 cases) diagnosed at the pathology department, National cancer institute, Cairo-university. Results: CEP 17 polysomy showed a significant association with TOP2A abnormalities, and a trend towards better prognosis in patients with these abnormalities, So making studies on larger sample size may give significant association. Disease outcome, status of the disease (either locally advanced or advanced) and radiotherapy intake showed a significant association with overall survival. Disease free survival had a significant association between disease outcome and tumor grade |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ki-67 LI |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TNBC |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TOP2A |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Ramadan Nassar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman loay Hussein , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Ali Abdelfattah Sakr , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2018.Ma.T | 01010110077457000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2018.Ma.T | 01020110077457000 | 22.09.2023 | CD - Rom | 77457.CD |