Frequency and prognostic significance of RUNX1 gene amplification in Egyptian pediatric patients with precursor B- cell acute lymphoblastic leukemia / (Record no. 71432)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03090cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032244.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190413s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.05.Ph.D.2018.Wa.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Walaa Elsayed Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Frequency and prognostic significance of RUNX1 gene amplification in Egyptian pediatric patients with precursor B- cell acute lymphoblastic leukemia / |
| Statement of responsibility, etc. | Walaa Elsayed Mohamed ; Supervised Shrief Aboulnaga Abuolnaga , Iman Abdelmokhales Sidhom , Shrine Ibrahim Salem |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | معدل حدوث والمدلول التكهني للتضخيم الجيني رن اكس 1 في الاطفال المصريين المصابين بسرطان الدم الليمفاوي الحاد من نوع الخلايا ب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Walaa Elsayed Mohamed , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 157 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Purpose: To evaluate the frequency of intrachromosomal amplification of chromosome 21(iAMP21) in pediatric patients with B-cell precursor acute lymphoblastic leukemia, to study its relation to clinical as well as biological features of the patients and to assess its prognostic significance. Methods: Pediatric patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL), who were treated at children cancer hospital Egypt 57357 from the year 2009 to 2011 on St. Jude total study XV protocol were retrospectively screened with ETV6/RUNX1-specific fluorescent in situ hybridization (FISH) probe for the presence of iAMP21. Results: In total, 518 patients were included. iAMP21 was found in 2% of the patients. The median age for iAMP21patients was 6.7 years and the median value of white blood cell count was 6.2 x 10³/mL. None of the patients had Pro-B immunophenotype. About 44% of the patients with iAMP21 had slow early response compared to 17% in the no iAMP21 group (p =0.031). Among iAMP21 patients, those with negative MRD at the end of the induction and received intermediate risk treatment didn't have relapses. On the other hand, 2 out of the 5 patients who received the low risk treatment had relapses despite MRD negativity at the end of the induction. Conclusion: The presence of iAMP21 was related to slow early response to induction treatment and was likely associated with lower RFS compared to patients without iAMP21 (66.7±15.7% v 84.7±1.7%; p=0.205 respectively). So, those patients will benefit from receiving more intensive chemotherapy regimens |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | BCP-ALL |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FISH |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IAMP21 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Abdelmokhales Sidhom , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shrief Aboulnaga Abuolnaga , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shrine Ibrahim Salem , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.05.Ph.D.2018.Wa.F | 01010110077756000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.05.Ph.D.2018.Wa.F | 01020110077756000 | 22.09.2023 | CD - Rom | 77756.CD |