Pharmaceutical study of resveratrol alone and combined with photothermal effect of gold nanoparticles / (Record no. 71474)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02970cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032245.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180415s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.24.03.M.Sc.2018.Ab.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Abdullah Ibrahim Elkholy |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmaceutical study of resveratrol alone and combined with photothermal effect of gold nanoparticles / |
| Statement of responsibility, etc. | Abdullah Ibrahim Elkholy ; Supervised Maha Fadel Mohamed , Kawser Nazmi Kassab , Tareq Youssef |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلانية لعقار الريزفيراترول منفردا ومقترنا مع التأ ثير الضوئي الحراري لجسيمات الّذهب النانوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Abdullah Ibrahim Elkholy , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 83 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Applications in Medical Biological |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This work basically studies the effect of gold nanoparticles, as a drug delivery and photothermally active system, on the cytotoxicity of resveratrol, a natural polyphenol produced by several plants. Gold nanoparticles used for loading were synthesized by the direct reaction between resveratrol itself, as a reducing agent, and chloroauric acid in aqueous medium. Surface plasmon resonance (SPR) and average diameter of the synthesized resveratrol-mediated gold nanoparticles (R*AuNPs) was at 533 nm and ~17 nm respectively. Transmission Electron Microscopy (TEM) imaging showed that the majority of R*AuNPs were spherical or semi-spherical in shape with a distinct coat obviously observed around each particle. Coating material of R*AuNSs was isolated and analyzed using mass spectrometry and FT-IR spectrometry that revealed its polymeric or oligomeric nature meaning that resveratrol underwent oxidative polymerization during the synthesis process.Resveratrol, as a chemotherapeutic agent, was then loaded onto R*AuNSs, using Tween-20 as a linker, with loading capacity up to 11.6 % w/w. R*AuNSs and Resveratrol loaded R*AuNSs (R-R*AuNSs) showed good stability in aqueous media. Release of resveratrol from R*AuNSs in vitro was found to follow zero order kinetics with initial burst release. Cytotoxicity of free and loaded resveratrol (R and R-R*AuNSs) as well as free gold nanospheres (R*AuNSs) was examined under both dark and irradiation conditions using HepG2 cells as a model for cancer cells |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gold nanoparticles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Photothermal |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Resveratrol |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kawser Nazmi Kassab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Fadel Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tareq Youssef , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.24.03.M.Sc.2018.Ab.P | 01010110077767000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.24.03.M.Sc.2018.Ab.P | 01020110077767000 | 22.09.2023 | CD - Rom | 77767.CD |