Evaluating the safety and anticancer activity of artemisia herba alba extract compared to the semi-synthetic derivative artesunate in ehrlich solid carcinoma bearing mice / (Record no. 71690)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02633cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032251.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190424s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2018.Ah.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Salih Ahmed Elfaky |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluating the safety and anticancer activity of artemisia herba alba extract compared to the semi-synthetic derivative artesunate in ehrlich solid carcinoma bearing mice / |
| Statement of responsibility, etc. | Ahmed Salih Ahmed Elfaky ; Supervised Mahmoud Ahmed Amer , Hanan Ramadan Hamad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم السلامة و النشاط المضاد للسرطان لمستخلص الأرتميسيا هربا ألبا مقارنة بالمشتق شبه الصناعي: أرتيسونيت في الفئران الحاملة لسرطان ايرليش الصلب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Salih Ahmed Elfaky , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 104 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology (Physiology Immunology) |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The search for new anticancer drugs targeted cancer cells selectivelywithout side effects is an important task because of various side effects caused bychemotherapeutic drugs.Thus, our study was performed to assess the safety andanticancer activity of the Artemisia herbaalbaextract compared to the semisyntheticdrug Artesunatein mice. The oral administration of Artemisia herbaalbacaused single and double stranded DNA breaks leading to apoptosis of tumor cellsas revealed by the smeared pattern of genomic DNA through elevations of p53expression levels in conjunction with decreasing K-ras expression levels in a timedependent manner similar to Artesunateand better than Cisplatin. The apoptosis oftumor cells was further confirmed by the appearance of apoptotic and necrotictumor cells as well as the infiltrations of mononuclear cells into the tumor sectionsof the treated groups.Minor histological lesions were observed in the liver andkidney tissues sections of Artemisia extract group compared to the high histologicallesions observed in the liver and kidney tissues of Artesunateand Cisplatin groups |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer efficacy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Artemisia herbaalba |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Artesunate |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Ramadan Hamad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Ahmed Amer , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2018.Ah.E | 01010110077948000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2018.Ah.E | 01020110077948000 | 22.09.2023 | CD - Rom | 77948.CD |