Evaluation of the osteomodulator and cardiovascular protective effect of in combination with risedronate, raloxifene and strontium ranelate in an osteoporotic rat model / (Record no. 71729)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03568cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032252.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190502s2018 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.Ph.D.2018.Am.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amira karam Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the osteomodulator and cardiovascular protective effect of in combination with risedronate, raloxifene and strontium ranelate in an osteoporotic rat model / |
| Statement of responsibility, etc. | Amira karam Mahmoud ; Supervised Soheir Abou Elazm Diab , Ghada Mohamed Abdelzaher Hashem , Mira Farouk Youssef |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التأثير المحور لأستجابة خلايا العظام و الواقى للقلب والأوعيه الدمويه للسيمفاستاتين منفردا و بالأضافه لأى من ريزيدرونات: رالوكسيفين و سترانشيوم رانيلات على نموذج هشاشة العظام المستحدث فى الجرذان البيضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amira karam Mahmoud , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 194 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Osteoporosis is one of the deleterious side effects of long-term glucocorticoid therapy. The side-effects of the currently available osteoporotic therapies and their ability to increase bone mass is relatively small not more than 2% per year so, there is a need for novel drug therapies for the treatment of osteoporosis. Evidence that osteoporosis and cardiovascular diseases are positively correlated. Therefore, the attention has driven toward the importance of possible synergism that might occur from combination of anti resorpative medications with simvastatin. Aim of the work: Assess the osteomodulatory and cardio vascular protective effect of Simvastatin, residronate, strontium ranelate and raloxifene separately and their combination with simvastatin in rat model of glucocorticoid induced osteoporosis. Methodology: A 72 Mature healthy albino rats of both sex are randomly allocated into 9 main groups and received drugs for 6weeks by oral gavage. G1: Normal control group,G2:osteoprotic treated group received prednisolone (pred) at 30 mg/kg per 2 days ,G3:Simvastatin(Sim)- treated group received simvastatin at10mg/kg/day,G4:Residronate (Residr)- treated group received residronate at 1mg/kg/day), G5: Strontium (SR)-treated group received strontium at 600mg/kg/day,G6:raloxifene (RAL)-treated group, received raloxifene at 1.25mg/kg/day, G7:SIM+Residr-treated group,G8:Sim +SR treated group and G9:Sim +RAL treated group. At the end of 6 weeks ,all studied groups were assessed pharmacologically by measurement of mean arterial blood pressure (MAP), ECG and echocardiography, biochemically, by measurement of serum Ca, P, osteocalcin(OCN), bone specific alkaline phosphatase (BSAP),ALT and AST. Histologically by assessment of bone cortical thickness, histopathological scoring and bone mineral density by DEXA scan was also recorded |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antiresorpative medication |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glucocorticoids |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Simvastatin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mohamed Abdelzaher Hashem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mira Farouk Youssef , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Abou Elazm Diab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.Ph.D.2018.Am.E | 01010110077826000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.Ph.D.2018.Am.E | 01020110077826000 | 22.09.2023 | CD - Rom | 77826.CD |