Possible effects of exenatide on osteoporosis, depression and myocardial infarction experimentally induced in adult female albino rats / (Record no. 71730)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03119cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032252.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190502s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.Ph.D.2018.Os.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Osama Mohamed Abutaleb |
| 245 10 - TITLE STATEMENT | |
| Title | Possible effects of exenatide on osteoporosis, depression and myocardial infarction experimentally induced in adult female albino rats / |
| Statement of responsibility, etc. | Osama Mohamed Abu Taleb ; Supervised Nahed Mahmoud Moussa , Hesham Attia Awad , Rahma Kamal Eldine Abou Elnour |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثيرالمحتمل للاكزيناتيد علي هشاشة العظام و الاكتئاب و جلطة القلب المحدثين معمليا في إناث الجرذان البيضاء البالغة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Osama Mohamed Abutaleb , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 149 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Post-menopausal females are categorized as a high risk group for osteoporosis, depression and major cardiovascular events. Although several drugs are currently used for treatment of depression, these drugs are known to alleviate the symptoms but have some limitations owing to their severe side effects and their cardioprotective effects are not well established. Consequently, looking for new agents that are equally or more effective and cause fewer side effects is urgently needed. The aim of this work: was to study the possible protective and therapeutic effects of exenatide on experimentally induced osteoporosis, depression and myocardial infarction in adult ovariectomized female albino rats. Methods: Forty eight mature female albino rats, matched for age and weight (150-250 gm) were used. Osteoporosis and depression were experimentally induced by bilateral ovriectomy (OVX) and leaving the animals for 6 weeks without treatment. Rats were divided into 4 groups.Group-I (Sham group) was exposed to Sham opertion, ovariectomized (OVX) group-II [OVX non treated], prophylactic exenatide group-III (received prophylactic exenetide (1og/kg/d SC) for 6 weeks following OVX) and group IV (OVX + treatment for 8 weeks). Group IV was sudivided into 3 subgroups, group-IVa (treated by vitamin D 0.25æg/day orally for 5 days per week), IVb (treated by fluoxetine 10 mg/kg/day orally) and IVc (treated by exenatide1og/kg/d SC). Assesment of depression was done by recording active swimming time (AST) in forced swimming test (FST) and, ambulation score (AS) and rearing number (RN), in open field tests OFT |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Depression |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Myocardial infarction |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoporosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hesham Attia Awad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nahed Mahmoud Moussa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rahma Kamal Eldine Abou Elnour , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.Ph.D.2018.Os.P | 01010110077827000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.Ph.D.2018.Os.P | 01020110077827000 | 22.09.2023 | CD - Rom | 77827.CD |