Significance of neuropilin-1 expression in acute myeloid leukemia / (Record no. 71810)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03030cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032255.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190505s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2018.So.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Soad Alsayed Eltokhy |
| 245 10 - TITLE STATEMENT | |
| Title | Significance of neuropilin-1 expression in acute myeloid leukemia / |
| Statement of responsibility, etc. | Soad Alsayed Eltokhy ; Supervised Basma Elgamal , Yasser Elnahass , Fatma Elrefaey |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة أهمية النيوربيلين 1 في اللوكيميا الميودية الحادة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Soad Alsayed Eltokhy , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 172 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Neuropilins are single-pass trans-membrane glycoproteins that were found to be receptors for the vascular endothelial growth factor (VEGF) family of angiogenesis factors, VEGF is an important cytokine that contributes to disease evolution in various myeloid neoplasms. Aim of the work : the aim of study was to evaluate Neuropilin-1(NRP-1) gene expression Pattern in AML patients and its role in disease severity and progression. Patients and Methods: In our study ,we analysed NRP-1 expression level in 50 de novo AML patients and 10 healthy subjects as controls using real -time PCR. Results: The present study included 33 males (66%) and 17 females (34%) ,their ages ranged from 1 to 73 years with a median of (34.5 ) ,a cut-off value of 60.2 (Relative Quantitation) was established statistically to dichomatize patients into two groups, High and Low NRP-1 expressors . A statistically significant correlation between high Neuropilin-1 expression was associated with monocytic differentiated FAB (M4 and M5) patients (P value = 0.002).There was also a significant correlation between high expression of NRP-1 and organomegaly (p value <0.001) . As well as between NRP1 fold -change and BM blasts ( r = 0.653, p=0.004) . In addition, there was a trend of high NRP-1 expression to be associated with PB blasts (P value = 0.099) . And there was a statistically significant impact between NRP-1 high expression and development of complications (P value < 0.001). There was no relation between NRP1 and Lab parameters , sex or age , however, younger age was associated with high NRP-1 expression (P value =0.049). There was no relation between NRP-1 and cytogenetic risk classes or FLT3 gene expression and overall survival of AML patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AML |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FAB monocytic leukemias |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | NRP-1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Basma Elgamal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Elrefaey , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yasser Elnahass , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2018.So.S | 01010110077990000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2018.So.S | 01020110077990000 | 22.09.2023 | CD - Rom | 77990.CD |