Study of MicroRNA 196a and 499 polymorphisms in hepatocellular carcinoma patients / (Record no. 71884)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02995cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032258.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190509s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2018.As.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Mohamed Fteah Abdelaziz |
| 245 10 - TITLE STATEMENT | |
| Title | Study of MicroRNA 196a and 499 polymorphisms in hepatocellular carcinoma patients / |
| Statement of responsibility, etc. | Asmaa Mohamed Fteah Abdelaziz ; Supervised Nehad Ahmed Mosaad , Mona Mohamed Hassan , Asmaa Ismail Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى مرضى سرطان الكبد MICRORNA 196A and 499 دراسة تأثير التعددات الشكلية لـــ |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Mohamed Fteah Abdelaziz , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 170 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hepatocellular carcinoma (HCC) is the commonest primary tumor of the liver. MicroRNAs (miRNAs) can generate different functions for regulating RNA protein levels and balancing abnormalities. Single nucleotide polymorphisms (SNPs) in miRNAs were reported to increase patient susceptibility to cancer development and affect prognosis and survival. Objective: To evaluate MiRNA 196a2 (rs11614913) C>T and MiRNA 499 (rs3746444) A>G as potential biomarkers for HCV-related HCC development in Egyptian patients. Subjects and methods: A case-control study included 75 HCV-related HCC patients, 75 cirrhotic patients on top of HCV infection and 75 healthy controls. Genotyping of the candidate SNPs was performed by Real Time PCR. Liver and kidney function tests, hepatitis B and C markers and AFP were performed. Results: There was a significant difference in miRNA 499 (rs3746444) genotypes frequency between the three studied groups (p=0.009) and the combined microRNA 499 (AA+AG) genotypes were significantly higher in HCC cases than in cirrhosis and normal control groups (p=0.005). The frequency of the G allele was significantly lower in HCC cases than other groups (p=0.024) and significantly lower in HCC cases than normal control group (p=0.006) and [OR (95%CI) = 0.501 (0.304-0.825)]. Median AST, ALT, ALP, total bilirubin and direct bilirubin levels were found to be significantly lower in patients with GG genotype than those with (AA+AG) genotypes with (p = 0.002, 0.036, 0.006, 0.021 and 0.01) respectively. For miRNA 196a2 (rs11614913) C>T polymorphisms, no significant association was found with the risk for HCC development |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gene polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCC |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA 196a2 C>T |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Ismail Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mohamed Hassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nehad Ahmed Mosaad , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2018.As.S | 01010110077877000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2018.As.S | 01020110077877000 | 22.09.2023 | CD - Rom | 77877.CD |