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Study of MicroRNA 196a and 499 polymorphisms in hepatocellular carcinoma patients / (Record no. 71884)

MARC details
000 -LEADER
fixed length control field 02995cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032258.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190509s2018 ua d f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2018.As.S
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Asmaa Mohamed Fteah Abdelaziz
245 10 - TITLE STATEMENT
Title Study of MicroRNA 196a and 499 polymorphisms in hepatocellular carcinoma patients /
Statement of responsibility, etc. Asmaa Mohamed Fteah Abdelaziz ; Supervised Nehad Ahmed Mosaad , Mona Mohamed Hassan , Asmaa Ismail Ahmed
246 15 - VARYING FORM OF TITLE
Title proper/short title فى مرضى سرطان الكبد MICRORNA 196A and 499 دراسة تأثير التعددات الشكلية لـــ
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Asmaa Mohamed Fteah Abdelaziz ,
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 170 P. :
Other physical details charts ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Background: Hepatocellular carcinoma (HCC) is the commonest primary tumor of the liver. MicroRNAs (miRNAs) can generate different functions for regulating RNA protein levels and balancing abnormalities. Single nucleotide polymorphisms (SNPs) in miRNAs were reported to increase patient susceptibility to cancer development and affect prognosis and survival. Objective: To evaluate MiRNA 196a2 (rs11614913) C>T and MiRNA 499 (rs3746444) A>G as potential biomarkers for HCV-related HCC development in Egyptian patients. Subjects and methods: A case-control study included 75 HCV-related HCC patients, 75 cirrhotic patients on top of HCV infection and 75 healthy controls. Genotyping of the candidate SNPs was performed by Real Time PCR. Liver and kidney function tests, hepatitis B and C markers and AFP were performed. Results: There was a significant difference in miRNA 499 (rs3746444) genotypes frequency between the three studied groups (p=0.009) and the combined microRNA 499 (AA+AG) genotypes were significantly higher in HCC cases than in cirrhosis and normal control groups (p=0.005). The frequency of the G allele was significantly lower in HCC cases than other groups (p=0.024) and significantly lower in HCC cases than normal control group (p=0.006) and [OR (95%CI) = 0.501 (0.304-0.825)]. Median AST, ALT, ALP, total bilirubin and direct bilirubin levels were found to be significantly lower in patients with GG genotype than those with (AA+AG) genotypes with (p = 0.002, 0.036, 0.006, 0.021 and 0.01) respectively. For miRNA 196a2 (rs11614913) C>T polymorphisms, no significant association was found with the risk for HCC development
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Gene polymorphism
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term HCC
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term MicroRNA 196a2 C>T
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Asmaa Ismail Ahmed ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mona Mohamed Hassan ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Nehad Ahmed Mosaad ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Samia
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2018.As.S 01010110077877000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2018.As.S 01020110077877000 22.09.2023 CD - Rom 77877.CD