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Prognostic impact of CXCR4 and VLA4 expression in acute myeloid leukemia patients / (Record no. 71886)

MARC details
000 -LEADER
fixed length control field 02886cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032258.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190509s2018 ua d f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.11.07.Ph.D.2018.Ra.P
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Rania Soliman Hamza Awad
245 10 - TITLE STATEMENT
Title Prognostic impact of CXCR4 and VLA4 expression in acute myeloid leukemia patients /
Statement of responsibility, etc. Rania Soliman Hamza Awad ; Supervised Manal Mohamed Wagdi Elmasry , Doha Abdelhamid Mokhtar , Ola Mohamed Reda Khorshid
246 15 - VARYING FORM OF TITLE
Title proper/short title التأثير التكهنى للتعبير عن (سى إكس سى آر ٤) و ({uئآ٦ؤ}ـى آل إيه ٤) فى مرضى سرطان الدم الميلودى الحاد
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Rania Soliman Hamza Awad ,
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 217 P. :
Other physical details charts ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 ## - SUMMARY, ETC.
Summary, etc. Introduction: A great number of distinct antigens affect AML prognosis and prediction. Nevertheless, difficulties are still found in performing accurate risk stratification for diagnoses based on immunophenotypic features. Improving the accuracy of prognostic assessment of AML may allow the treatment to be more specific and risk-adapted. Here, we measured CXCR4, VLA-4 and CD200 expressions in leukemic myeloblasts to determine their prognostic implications. Methods: Using multicolor flow cytometry, our studied markers expressions were measured in leukemic myeloblasts in bone marrow aspirates that were obtained from newly diagnosed adult AML patients (n=80). Median values of the studied markers expression divided patients into high and low expressing groups. Results: High VLA-4 expression was associated with gum hyperplasia (p=0.028). FAB (M4, M5) was significantly higher within the high CXCR4 expressing group and nearly significant within the high VLA-4 expressing group (p=0.04 and 0.07 respectively). Among the 75 non-promyelocytic leukemia patients analyzed who received cytarabine + anthracycline-based induction chemotherapy, high VLA-4 expression was associated with longer disease free survival (p=0.005) and progression free survival (p=0.009) and a trend of longer overall survival. High CD200 was associated with longer overall survival (p=0.042) and progression free survival (p=0.044)
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Acute myeloid leukemia (AML)
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term CXC chemokine receptor 4 (CXCR4)
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Very late antigen 4 (VLA-4)
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Doha Abdelhamid Mokhtar ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Manal Mohamed Wagdi Elmasry ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Ola Mohamed Reda Khorshid ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Samia
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.11.07.Ph.D.2018.Ra.P 01010110077879000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.11.07.Ph.D.2018.Ra.P 01020110077879000 22.09.2023 CD - Rom 77879.CD