Prognostic impact of CXCR4 and VLA4 expression in acute myeloid leukemia patients / (Record no. 71886)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02886cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032258.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190509s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2018.Ra.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rania Soliman Hamza Awad |
| 245 10 - TITLE STATEMENT | |
| Title | Prognostic impact of CXCR4 and VLA4 expression in acute myeloid leukemia patients / |
| Statement of responsibility, etc. | Rania Soliman Hamza Awad ; Supervised Manal Mohamed Wagdi Elmasry , Doha Abdelhamid Mokhtar , Ola Mohamed Reda Khorshid |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير التكهنى للتعبير عن (سى إكس سى آر ٤) و ({uئآ٦ؤ}ـى آل إيه ٤) فى مرضى سرطان الدم الميلودى الحاد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rania Soliman Hamza Awad , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 217 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: A great number of distinct antigens affect AML prognosis and prediction. Nevertheless, difficulties are still found in performing accurate risk stratification for diagnoses based on immunophenotypic features. Improving the accuracy of prognostic assessment of AML may allow the treatment to be more specific and risk-adapted. Here, we measured CXCR4, VLA-4 and CD200 expressions in leukemic myeloblasts to determine their prognostic implications. Methods: Using multicolor flow cytometry, our studied markers expressions were measured in leukemic myeloblasts in bone marrow aspirates that were obtained from newly diagnosed adult AML patients (n=80). Median values of the studied markers expression divided patients into high and low expressing groups. Results: High VLA-4 expression was associated with gum hyperplasia (p=0.028). FAB (M4, M5) was significantly higher within the high CXCR4 expressing group and nearly significant within the high VLA-4 expressing group (p=0.04 and 0.07 respectively). Among the 75 non-promyelocytic leukemia patients analyzed who received cytarabine + anthracycline-based induction chemotherapy, high VLA-4 expression was associated with longer disease free survival (p=0.005) and progression free survival (p=0.009) and a trend of longer overall survival. High CD200 was associated with longer overall survival (p=0.042) and progression free survival (p=0.044) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acute myeloid leukemia (AML) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CXC chemokine receptor 4 (CXCR4) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Very late antigen 4 (VLA-4) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doha Abdelhamid Mokhtar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manal Mohamed Wagdi Elmasry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Mohamed Reda Khorshid , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2018.Ra.P | 01010110077879000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2018.Ra.P | 01020110077879000 | 22.09.2023 | CD - Rom | 77879.CD |