Neuroprotective evaluation of certain antiepileptic drugs on 3-nitropropionic acid-induced neurotoxicity in rat / (Record no. 72031)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02528cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032303.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190519s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2018.He.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Nasr Mohamed Moustafa |
| 245 10 - TITLE STATEMENT | |
| Title | Neuroprotective evaluation of certain antiepileptic drugs on 3-nitropropionic acid-induced neurotoxicity in rat / |
| Statement of responsibility, etc. | Heba Nasr Mohamed Moustafa ; Supervised Hala Fahmy Zaki , Dalia Moustafa Eltanbouly |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم فعالية بعض الأدوية المضادة للصرع فى الوقاية من التسمم العصبى المحدث بواسطة حمض 3-نيترو بروبيونيك فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Heba Nasr Mohamed Moustafa , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 146 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Prevalence of glutamate receptor subunit 2 (GluR2)-lacking Ü-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors is a hallmark of excitotoxicity-related neurodegenerative diseases. Topiramate (TOP) is a structurally novel anticonvulsant with a well-known modulatory effect on AMPA/kainate subtypes of glutamate receptors. Levetiracetam (LEV) is a unique anti-epileptic acting mainly via inhibition of glutamate release. The present study aimed at investigating the neuroprotective potentials of TOP and LEV on 3-nitropropionic acid (3-NP)-induced striatal neurodegeneration and Huntington's disease (HD)-like symptoms. Rats were injected with 3-NP (10 mg/kg/i.p.) for 14 days, TOP (50 mg/kg/p.o.) and LEV (100mg/ kg/p.o.) were given once a day, 1 h before 3-NP. Administration of TOP and LEV amended 3-NP induced changes in neurobehavioral performance, striatal neurotransmitters levels and histopathological injury. 3-NP control rats showed a significant ablation in the mRNA expression of Ca2+-impermeable Glu2R subunit along with an elevation in its regulatory protein PICK1, an effect that was largely reversed by TOP and LEV |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AMPA |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GluR2 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glutamate |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Moustafa Eltanboul , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2018.He.N | 01010110077896000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2018.He.N | 01020110077896000 | 22.09.2023 | CD - Rom | 77896.CD |