Effects of drugs acting on potassium channels in rotenone-induced dopaminergic cell death in mice / (Record no. 72032)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02929cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032303.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190519s2018 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2018.He.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Tallah Ahmed Mohamed Farid Shaaban |
| 245 10 - TITLE STATEMENT | |
| Title | Effects of drugs acting on potassium channels in rotenone-induced dopaminergic cell death in mice / |
| Statement of responsibility, etc. | Heba Tallah Ahmed Mohamed Farid Shaaban ; Supervised Ezz Eldin Saeed Eldenshary , Hala Fahmy Zaki , Omar M. Abdelsalam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الأدوية التى تعمل على قنوات البوتاسيوم فى موت خلايا الدوبامين المحدث بواسطة الروتينون فى الفئران |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Heba Tallah Ahmed Mohamed Farid Shaaban , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 210 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study aimed to investigate the effect of KATP channel opening with nicorandil or blockade with glibenclamide on neurodegeneration in mice following systemic rotenone injection. Mice were treated with rotenone (1.5 mg/kg subcutaneously; 3 times/week on days 1, 3, 5) for 3 successive weeks. Starting on the 1st day of rotenone treatment, mice were daily treated intraperitoneally with either nicorandil (6 or 10 mg/kg), glibenclamide (3 or 5 mg/kg) or l-dopa (25 mg/kg). Behavioral examination using the wire hanging and stair tests were performed. Striatal levels of dopamine, tyrosine-hydroxylase, caspases (3, 8, 9), Bcl-2, and tumor necrosis factor-Ü (TNF-Ü) were determined. Rotenone injection resulted in a decrease in motor strength and activity in mice. In addition, striatal apoptosis was evidenced by decreased level of the antiapoptotic protein Bcl-2, the increase in the apoptotic markers caspase 3, 8 and 9 as well as by histopathological alterations. Treatment with glibenclamide and l-dopa exerted a neuroprotective effect as revealed by the increase of Bcl2, tyrosine-hydroxylase and dopamine while decreasing caspase 3, 8, 9 and TNF- Ü immunoreactivity. On the other hand, nicorandil administration didn{u2019}t ameliorate rotenone-induced striatal neurodegeneration. These data suggest an antiapoptotic and anti-inflammatory action for glibenclamide and l-dopa in the rotenone model of Parkinson{u2019}s disease in mice |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glibenclamide |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | KATP channels |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nicorandil |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezz Eldin Saeed Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omar Mohamed Abdelsalam , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2018.He.E | 01010110077897000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2018.He.E | 01020110077897000 | 22.09.2023 | CD - Rom | 77897.CD |