Study of the possible neuroprotective effect of certain benzimidazole-containing drugs in experimentally induced Parkinson{u2019}s disease in rats / (Record no. 72057)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02734cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032304.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190520s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2018.Es.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Esraa Abdelaziz Kandil |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the possible neuroprotective effect of certain benzimidazole-containing drugs in experimentally induced Parkinson{u2019}s disease in rats / |
| Statement of responsibility, etc. | Esraa Abdelaziz Kandil ; Supervised Bahia Mohamed Elsayeh , Lamiaa Ahmed Attia , Mai Ahmed Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثير الوقائي العصبي المحتمل لأدوية معينة محتوية على البنزيميدازول في مرض الشلل الرعاش المستحدث تجريبياً في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Esraa Abdelaziz Kandil , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 115 P. : |
| Other physical details | charts , Facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Recently it was shown that nuclear receptor related 1 (Nurr1) play pivotal role in the development and survival of dopaminergic neurons, and its deficiency may be involved in Parkinson{u2019}s disease (PD) pathogenesis. Furthermore, it was revealed that hypoxia-inducible factor-1 alpha (HIF-1Ü) insufficiency and thrombin accumulation are involved in dopaminergic neurons degeneration. Fortunately, Albendazole (ABZ), antihelmintic benzimidazole,was proposed to activate Nurr1 via its benzimidazole group and was shown to promote HIF-1Ü transcription in vitro.Attractively, the new anticoagulant dabigatran etexilate (DE) is a direct thrombin inhibitor that owns benzimidazole group, which has been proposed to activate Nurr1.Therefore, the aim of this study was to explore the neuroprotective effects of ABZ and DE in a rotenone model of PD.Rotenone was injected subcutaneously at a dose of 1.5 mg/kg every other day for 21 days. An oral regimen of ABZ (10 mg/kg) and DE (15 mg/kg) was started after the 5th rotenone injection following the manifestations of PD. Treatment of PD rats with ABZ and DE mitigated rotenone-induced neuronal degeneration and restored striatal dopamine level with motor recovery |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Albendazole |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Dabigatran etexilate |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neuroprotection |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bahia Mohamed Elsayeh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Ahmed Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Ahmed Galal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2018.Es.S | 01010110078160000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2018.Es.S | 01020110078160000 | 22.09.2023 | CD - Rom | 78160.CD |