Study on the possible mechanisms involved in the antidiabetic effects of bromocriptine alone and or in combination with sitagliptin in Type 2 diabetic rats / (Record no. 72483)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03217cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032317.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190617s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2019.En.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Enji Reda Abdelaal Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Study on the possible mechanisms involved in the antidiabetic effects of bromocriptine alone and or in combination with sitagliptin in Type 2 diabetic rats / |
| Statement of responsibility, etc. | Enji Reda Abdelaal Ali ; Supervised Hanan Salah Eldin Elabhar , Nesrin Salah Eldin Elsayed , Sherifa Kamal Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة حول الآليات المحتملة لعلاج مرض السكري باستخدام دواء البروموكريبتين منفردا أو بمصاحبة السيتاجليبتين في الجرذان المصابة بمرض السكري من النوع الثاني |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Enji Reda Abdelaal Ali , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 120 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Bromocriptine (BC), a sympatholytic D2 receptor agonist, is an old drug used clinically for over 30 years to treat patients with PD and prolactinomas. Nevertheless, the new quick-release formulation of BC (bromocriptine-QR; Cycloset) was approved by the FDA in May 2009, as a novel therapeutic option in T2DM. However, the precise mechanisms are not completely unveiled. Hence, the objective of the current study is to clarify the potential molecular pathways of the insulin sensitizing effect of BC in the skeletal muscle of diabetic rats, a core peripheral organ in I/R/diabetes, and to evaluate its possible interaction with sitagliptin (SG) as an add-on therapy. The latter was chosen as the standard antidiabetic drug used herein. Here, the experimental model impersonates unhealthy dietary habit and T2DM was adopted, in which rats were fed high caloric diet of fat and fructose for 6 weeks followed by a single sub-diabetogenic dose of streptozotocin (STZ) (35 mg/kg; HF/Fr/STZ). Diabetic rats were treated with BC, SG at two dose levels (SG10 and SG20) and combination of BC+SG10 for 2 weeks.Several parameters have been settled to appraise the possible mechanisms of the tested drugs. Besides the glucose homeostasis and lipid profile-related parameters and GLP-1, the inflammatory pathway (leptin-IL-6/JAK2/p-STAT3/SOCS3), the insulin signaling cue (p-IR/p-AKT/GLUT4), and the PPAR-Þ/adiponectin trajectory in the soleus skeletal muscle of diabetic rat were gauged. Moreover, Nrf-2 and PARP-1 were assessed in the soleus skeletal muscle to measure the antioxidant capacity of tested drugs |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antidiabetic |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bromocriptine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sitagliptin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah Eldin Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nesrin Salah Eldin Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherifa Kamal Ahmed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2019.En.S | 01010110078447000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2019.En.S | 01020110078447000 | 22.09.2023 | CD - Rom | 78447.CD |