MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02153cam a2200301 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190625s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.10.Ph.D.2018.Em.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Emad Abdullah Deeb |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis of some new pyrazoles and their fused derivatives as antitumor agents / |
| Statement of responsibility, etc. |
Emad Abdullah Deeb ; Supervised Nadia Hanafy Metwally |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تشييد بعض البيرازولات الجديدة ومشتقاتها الملتحمة كمضادات للأورام |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Emad Abdullah Deeb , |
| Date of publication, distribution, etc. |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
200 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The original work of this thesis includes: The key intermediate 3-aminopyrazolo[4,3-c]pyridine-4,6-dione (2) is considered as a precursor for some novel pyrazolo[4,3-c]pyridines such as 5a-c, 6a-c, arylhydrazopyrazolo[4,3-c]-pyridines 8a-e pyrazolo[4,5,1-ij][1,6] naphthyridines 11a-e, 18a-d and pyrido[4',3':3,4]pyrazolo[1,5-a]-pyrimidines 15a-d, 19a-p through Knovenegal condensation, coupling reaction and Michael addition. The structures were confirmed by elemental analyses, spectral data and all possible have been postulated to account for their formation. Some of the newly synthesized pyrazolo[4,3-c]pyridine derivatives were investigated for anticancer activity. The results of the cytotoxic activity revealed that compound 6b was the most active compound against the breast and liver carcinoma cell lines which gives IC50 values of 1.937 and 3.695 æg/mL, respectively compared to reference drug (doxorubicin) with IC50 values of 2.527 and 4.749 æg/ml, respectively |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
3-Aminopyrazolo [4,3-c]-pyridine-4,6-dione |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
3-Cyanomethyl-4-cyano-5-amino-1H-pyrazole |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyrazolo[4,3-c]pyridines |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nadia Hanafy Metwally , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Asmaa |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
