The protective role of insulin alone, in combination with metformin or sitagliptin against early cardiac dysfunction in streptozotocin-induced diabetic rats / (Record no. 72638)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02930cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032321.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190703s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.M.Sc.2018.Ge.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gehad Sayed Ahmed Fadl |
| 245 14 - TITLE STATEMENT | |
| Title | The protective role of insulin alone, in combination with metformin or sitagliptin against early cardiac dysfunction in streptozotocin-induced diabetic rats / |
| Statement of responsibility, etc. | Gehad Sayed Ahmed Fadl ; Supervised Amani Nabil Shafik , Mohamed Elsayed Mahmoud , Walaa Wadie Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور الوقائي للأنسولين بمفرده: مع الميتفورمين: أو السيتاجليبتين ضد الاضطرابات القلبية الوظيفية المبكرة في البوال السكري المحدث بالستربتوزوتوسينفي الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Gehad Sayed Ahmed Fadl , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 140 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Cardiac affection is common in diabetic patients. Although insulin exerts a cardioprotective role, it may not be enough to totally prevent this affection. Sitagliptin or metformin combined with insulin not only help controlling the bloodglucose, but they also have a direct cardioprotective effect. Methods:An experimental study was done on 60 male albino rats for a duration of 42 days. Diabetes mellitus (DM) was induced bya single intraperitoneal injection of streptozotocin (60 mg). After confirming DM, rats were treated witheither insulin alone in two different doses (3 and 6 IU) or insulin (3 IU) and metformin (300 mg/Kg/day) or sitagliptin (10 mg/Kg) (n=10). Echocardiography was done at days 14, 28 and at the end of experimental procedures.Blood samples were collected for estimation of serum levels of random blood glucose, tumor necrosis factor alpha, interleukin-6 and brain natriuretic peptide. Results:DM significantly affected the cardiac condition very early as evidenced by deterioration of ejection fraction and other echocardiographic and laboratory parameters compared to non-diabetic rats. Treatment of DM with insulin and control of blood glucose prevented the deterioration of the cardiac condition.The addition of either metformin or sitagliptin significantly potentiate the cardioprotective effects of insulin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Albino rat |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cardioprotective |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes mellitus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amani Nabil Shafik , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Elsayed Mahmoud , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa Wadie Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.M.Sc.2018.Ge.P | 01010110078567000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.M.Sc.2018.Ge.P | 01020110078567000 | 22.09.2023 | CD - Rom | 78567.CD |