Determination of some drugs and prodrugs in combination with their degradation productsor active metabolites / (Record no. 72868)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02622cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032328.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190716s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2019.Gh.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ghada Hamdy Mahmoud Barakat |
| 245 10 - TITLE STATEMENT | |
| Title | Determination of some drugs and prodrugs in combination with their degradation productsor active metabolites / |
| Statement of responsibility, etc. | Ghada Hamdy Mahmoud Barakat ; Supervised Sonia Talaat Hassib , Elham Anwer Taha , Ehab Farouk Elkady |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقدير بعض الأدويه و طلائع الأدويه بالتواجد مع نواتج تكسيرها أونواتج الأيض النشطه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ghada Hamdy Mahmoud Barakat , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 243 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The study in this thesis included new analytical methods for the determination of some drugs and prodrugs in combination with their degradation products or active metabolites.Drugs cited in the thesis aresome antiviral drugs, antidiabeticdrugs and drugs used for treatment of inflammatory bowel disease. These methods include RP-LC method for simultaneous determination of seven antiviral drugs, the quantification was achieved at 254 nm for (acyclovir, ganciclovir, penciclovir and valaciclovir hydrochloride) and at 220 nm for (lamivudine, oseltamivir phosphate and ribavirin). Moreover, bioanalytical method for simultaneous determination of lamivudine and penciclovir in spiked human plasma wasdeveloped using valaciclovirHCl as internal standard. Validation of bioanalyticalmethod was performed according to European Medicines Agency guidelines.RP-LC method for determination of daclatasvirdihydrochloridewas developed and the study of its degradation behavior was investigated.Peak purity was checked for principle drug and its alkaline induced degradation product and the pathway of alkaline hydrolysis of daclatasvirdihydrochloride was suggested by LC/MS |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antidiabetic drugs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antiviral drugs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Drugs used for treatment of inflammatory bowel disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ehab Farouk Elkady , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Elham Anwer Taha , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sonia Talaat Hassib , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2019.Gh.D | 01010110078707000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2019.Gh.D | 01020110078707000 | 22.09.2023 | CD - Rom | 78707.CD |