The possible protective effect of ambroxol on cisplatin-induced hepato and nephrotoxicity in rats / (Record no. 72876)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02821cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032328.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190716s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2019.Ab.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Abeer Mokhtar Bishr |
| 245 14 - TITLE STATEMENT | |
| Title | The possible protective effect of ambroxol on cisplatin-induced hepato and nephrotoxicity in rats / |
| Statement of responsibility, etc. | Abeer Mokhtar Bishr ; Supervised Sanaa A. Kenawy , Azza S. Awad , Nada A. Sallam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير الوقائي المحتمل لدواء امبروكسول في تسمم الكبد والكلى المستحدث بالسيسبلاتين في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Abeer Mokhtar Bishr , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 117 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepato and nephrotoxicity are important drawbacks of cisplatin. The objective of this study is to evaluate the ability of ambroxol in two different doses (35 & 70 mg/kg, i.p.) to protect liver and kidney from damage induced by a single dose of cisplatin (10 mg/kg, i.p.) in comparison to N- acetylcysteine (250 mg/kg, i.p.). Oxidative stress, Inflammatory and apoptotic biomarkers were investigated to show the influence of ambroxol on hepato and nephrotoxicity. Ambroxol decreased the elevated activity of liver enzymes (ALT and AST) and kidney function tests (BUN and creatinine). Ambroxol mitigated cisplatin inflammatory damage by inhibition of tumor necrosis factor-Ü, interleukin-1Ý, nuclear factor kappa-B and elevation of nuclear factor erythroid 2-related factor 2 (Nrf2). Moreover, ambroxol inhibited oxidative damage indicated by reduction of malondialdehyde and replenished the store of reduced glutathione likely by upregulating glutathione reductase and superoxide dismutase. Elevation of phosphorylated c- Jun N-terminal kinases (p-JNK) and phosphorylated extracellular signal-regulated kinases (p-ERK) were attenuated by ambroxol associated with a decrease of the expression of caspase-3. These results were consistent with the histopathological results. These results recommend ambroxol to be co-administered with cisplatin in cancer patients to ameliorate liver and kidney damage and this was confirmed by MTT assay |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ambroxol |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cisplatin-induced hepato |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nephrotoxicity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Azza S. Awad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada A. Sallam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa A. Kenawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2019.Ab.P | 01010110078714000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2019.Ab.P | 01020110078714000 | 22.09.2023 | CD - Rom | 78714.CD |