Pharmacological study of the effect of some hepatoprotective substances on certain drug-induced hepatotoxic aspects / (Record no. 72953)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02759cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032330.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190718s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2019.Ma.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Rabie Khalil Saad |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacological study of the effect of some hepatoprotective substances on certain drug-induced hepatotoxic aspects / |
| Statement of responsibility, etc. | Marwa Rabie Khalil Saad ; Supervised Helmy Moawad Sayed Ahmed , Hala Mahmoud Fawzy , Dalia Moustafa Eltanbouly |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دوائية لتأثير بعض المواد الواقية للكبد ضد الجوانب السامة المستحدثة ببعض الأدوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Rabie Khalil Saad , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 150 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology ` |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Paracetamol is an extensively used analgesic and antipyretic drug. Overdose of paracetamol, however, is one of the prevailing causes of liver failure worldwide. The present investigation aimed at estimating the hepatoprotective activity of chicory and morus alba leaf extract against paracetamol-induced liver damage in rats, using silymarin as a reference standard. Both extracts (200 and 400 mg/kg, p.o.) were administered for four weeks while silymarin was administered for one week. One hour after the last dose of the tested agents, hepatotoxicity was induced by paracetamol (2 g/kg), orally administered to fasting rats in a single dose. Both doses of chicory and morus alba extracts significantly suppressed liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) activities and total bilirubin level as well as liver lesions evoked by paracetamol overdose. Concomitantly, chicory and morus alba extracts improved the hepatic oxidative status as manifested by elevation of liver nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant enzymes as glutamate cysteine ligase and hemeoxygenase-1 contents as well as glutathione reductase activity. They also raised liver glutathione redox ratio (Reduced glutathione/Oxidized glutathione) and repressed liver lipoperoxidation |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nrf2 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Paracetamol |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Moustafa Eltanbouly , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Mahmoud Fawzy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Helmy Moawad Sayed Ahmed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2019.Ma.P | 01010110078653000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2019.Ma.P | 01020110078653000 | 22.09.2023 | CD - Rom | 78653.CD |