The Possible protective effect of bone marrow transplantation with some natural products against cytogenetical aberrations and liver cell damage induced by carbon tetrachloride / (Record no. 73019)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02914cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032332.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190722s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2018.Em.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Eman Shafik Zaki |
| 245 14 - TITLE STATEMENT | |
| Title | The Possible protective effect of bone marrow transplantation with some natural products against cytogenetical aberrations and liver cell damage induced by carbon tetrachloride / |
| Statement of responsibility, etc. | Eman Shafik Zaki ; Supervised Ezz Eldin S. Eldenshary , Mohammed F. Elyamany , Muhammed Abdullatif saad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثير الوقائى المحتمل لزراعة نخاع العظم مع المنتجات الطبيعية ضد التشوهات الوراثية الخلوية وتدمير الخلايا الكبدية المستحدث برباعى كلوريد الكربون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Eman Shafik Zaki , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 168 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Liver fibrosis is a major health problem that can lead to liver cirrhosis and hepatic carcinoma. This study investigates the hepatoprotective effect of bone marrow mononuclear cells (BM-MNCs) transplantation, N-acetylcysteine (NAC) and Ü-lipoic acid (ALA) against hepatic toxicity and cytogenetical aberrations experimentally induced by carbon tetrachloride (CCl₄ in rats. Rats are administrated CCl4 (1mg/kg, i.p.) twice/week for 8 weeks showed elevation of liver enzymes ALT, AST in serum, liver tissue TNF-Ü, IL-6 inflammatory cytokines, while a reduction of albumin serum level and IL-10 anti-inflammatory cytokines, oxidative stress biomarkers as SOD, CAT, GPx, TAC liver tissue content accompanied by elevation of MDA liver content. In addition to cytogenetical aberration assessment via micronucleated polychromatic erythrocytes (MnPCEs) count, percent (%) of DNA damaged cells. Administration of BM-MNCs (1{u00D7}10⁶ in 0.1ml PBS, i.v.), NAC (300 mg/kg, p.o), ALA (100 mg/kg, p.o) alone and their combinations (BM-MNCs with NAC and BM-MNCs with ALA) decreased tissue content of TNF-Ü, IL-6, MDA, percentage of DNA damaged cells and MnPCEs and increase others as GPx, CAT, SOD, TAC and IL-10. Also, these agents produced marked reduction of liver enzymes ALT, AST, serum albumin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatoprotective agent |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezz Eldin S. Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed F. Elyamany , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muhammed Abdullatif saad , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2018.Em.P | 01010110078770000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2018.Em.P | 01020110078770000 | 22.09.2023 | CD - Rom | 78770.CD |