Expression of MicroRNAs 31, 155 and 29c and their relation to pathogenesis and severity of alopecia areata / (Record no. 73269)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02710cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032340.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190804s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.Ph.D.2019.Na.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nada Farouk Ibrahim Ismail |
| 245 10 - TITLE STATEMENT | |
| Title | Expression of MicroRNAs 31, 155 and 29c and their relation to pathogenesis and severity of alopecia areata / |
| Statement of responsibility, etc. | Nada Farouk Ibrahim Ismail ; Supervised Mohammed Bakr Mohammed Elwawahry , Iman Mohammed Amin , Iman Sany Zaky |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التعبيرعن المايكرو ار ان ايه 31 و 155 و 29 سي وعلاقته لمحتملة بحدوث وشدة مرض الثعلبة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nada Farouk Ibrahim Ismail , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 176 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background:Alopecia areata (AA) is a common autoimmune disorder that targets anagen hair follicles. The exact pathophysiology of AA remains unknown. The most widely accepted hypothesis is that it is a T-cell{u2013}mediated autoimmune condition that is most likely to occur in genetically predisposed individuals. Concerning the genetic basis of AA; immune genes have been identified as CTLA4 on chromosome 2q33.2, IL2/IL21 on chromosome 4q27, HLA on chromosome 6p21.32. AA preferentially affects pigmented hairs. Finally the role of micro RNA in AA is established in 2017 which can be a possible marker of severity. MicroRNAs (miRNAs) account for 1-5% of the human genome and regulate at least 30% of protein-coding genes. 940 distinct miRNAs molecules have been identified within the human genome. They are a large family of post-transcriptional regulators of gene expression, formed of a class of small, endogenous RNAs of 21{u2013}25 nucleotides in length and are implicated in disease etiology and treatment. Interestingly, miRNAs 31, 155 and 29c have shown an important role in alopecia areata. Since miRNA can be easily detected in different sample types such as tissues, serum, plasma and other body fluids so it can be used as serum biomarker in autoimmune diseases as alopecia areata |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alopecia areat |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiRNA 155 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiRNA 31 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Mohammed Amin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Sany Zaky , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Bakr Mohammed Elwawahry , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.Ph.D.2019.Na.E | 01010110078873000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.Ph.D.2019.Na.E | 01020110078873000 | 22.09.2023 | CD - Rom | 78873.CD |