The possible hepatoprotective effects of pranlukast and hamammelis against acetaminophen induced liver injury / (Record no. 73823)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03038cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032356.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190911s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2019.Re.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reham Hussein Mahmoud |
| 245 14 - TITLE STATEMENT | |
| Title | The possible hepatoprotective effects of pranlukast and hamammelis against acetaminophen induced liver injury / |
| Statement of responsibility, etc. | Reham Hussein Mahmoud ; Supervised Helmy Moawad Sayed Ahmed , Sherifa Kamal Ahmed , Muhammed Abdullatif Saad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير الوقائي المحتمل للبرانليوكاست والهاماميليس ضد إصابة الكبد المحدثة بواسطة الأسيتامينوفين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reham Hussein Mahmoud , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 117 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatic injury leading to hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades. Because APAP-induced liver injury is clinically relevant, well studied, and can be rapidly induced in vivo with a single dose, it has become a standard model in the pharmacotoxicological liver researches. In particular, APAP overdose in rodents is frequently used to test the hepatoprotective potential of herbal and non-herbal therapeutics. The present study focused on the elucidation of the potential protective effects of hamamelis extract and pranlukast against acetaminophen-induced hepatotoxicity. Silymarin was used as a standard hepatoprotective agent. A single dose of acetaminophen (800 mg\kg), injected intraperitoneally to male rats, caused a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver contents of malondialdehyde (MDA), hepatic tumor necrosis factor (TNF)-Ü and cytochrome-c (Cyt-c), in addition to hepatic activities of lipoxygenase (5-LOX), caspase-3 and myeloperoxidase (MPO as compared with the control group, while it significantly decreased reduced glutathione (GSH) content, as well as superoxide dismutase (SOD) activity. On the other hand, pre-administration of each of hamamelis extract (200 mg\kg\b.w), pranlukast (10 mg\kg\b.w) and silymarin (100 mg\kg\b.w) orally for 15 consecutive days significantly ameliorated the liver injury as exhibited by the histopathological investigation confirmed by the effect on the measured biochemical parameters |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acetaminophen |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antioxidant |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Helmy Moawad Sayed Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muhammed Abdullatif Saad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherifa Kamal Ahmed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2019.Re.P | 01010110079215000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2019.Re.P | 01020110079215000 | 22.09.2023 | CD - Rom | 79215.CD |