Infectious bronchitis viruses in Egypt : (Record no. 74118)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03449cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032406.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190924s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.03.Ph.D.2019.Ha.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hassanein Hassan Hassanein Abozeid |
| 245 10 - TITLE STATEMENT | |
| Title | Infectious bronchitis viruses in Egypt : |
| Remainder of title | Complete genome sequences and development of recombinant newcastle disease virus-vectored vaccines / |
| Statement of responsibility, etc. | Hassanein Hassan Hassanein Abozeid ; Supervised Manal Afify Aly Afifi , Sahar Ahmed Zouelfakar , Ayman Hany Eldeeb |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فيروسات التهاب الشاعب الهوائية المعدي في مصر : |
| Remainder of title | تسلسل الجينوم الكامل وتطوير لقاحات مدمجة من فيروس مرض النيوكاسل |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hassanein Hassan Hassanein Abozeid , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 118 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Animal Diseases |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In this study, we report the first record of complete genome sequences of two Egyptian IBV strains, CU/1/2014 and CU/4/2014, belonging to IBV genotypes GI-1 lineage and GI-23 lineage, respectively. Both strains have a common genome organization in the order of 5{u2032}-UTR-1a-1b-S-3a- 3b-E-M-4b-4c-5a-5b-N-6b-UTR-poly(A) tail-3{u2032}. The genome of strain CU/1/2014 is closely related to vaccine strain H120 but showed genome-wide point mutations in addition to novel 15-nt deletion in the 4b-4c gene junction region, suggesting that strain CU/1/2014 is probably a revertant of the vaccine strain H120. Recombination analysis of strain CU/4/2014 showed evidence for recombination involving at least three different IBV strains, namely, IT/90254/2005, 4/91, and H120. These results indicate continuous evolution of IBV field strains by genetic drift and by genetic recombination between field and vaccine strains. In order to overcome this issue, and to develop a vaccine that is more relevant to Egypt, a recombinant Newcastle disease virus (rNDV) strain LaSota was constructed to express the S glycoprotein of the Egyptian IBV variant strain CU/4/2014. A wildtype and two modified versions of the IBV S protein were expressed individually by rNDV. Singledose vaccination of 1-day-old chicks with the rNDVs expressing IBV S protein provided significant protection against the clinical disease after IBV challenge but did not show a reduction in tracheal viral shedding. Single-dose vaccination also provided complete protection against virulent NDV challenge. However, prime-boost vaccination using rNDV expressing the wild-type IBV S protein provided better protection against clinical signs and significantly reduced tracheal viral shedding. These results indicate that the NDV-vectored IBV vaccines are promising bivalent vaccine candidates to control both infectious bronchitis and Newcastle disease in Egypt |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Egyptian variant |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Genetic drift |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Infectious bronchitis virus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Hany Eldeeb , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manal Afify Aly Afifi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sahar Ahmed Zouelfakar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.03.Ph.D.2019.Ha.I | 01010110079244000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.03.Ph.D.2019.Ha.I | 01020110079244000 | 22.09.2023 | CD - Rom | 79244.CD |