MARC details
| 000 -LEADER |
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| fixed length control field |
02848cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190928s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.07.Ph.D.2019.Sa.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sarah Tareq Esmail Ali Sakna |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A phytochemical and biological study of certain Ziziphus species growing in Egypt / |
| Statement of responsibility, etc. |
Sarah Tareq Esmail Ali Sakna ; Supervised Marwan Marwan Shabana , Nabaweya Mostafa Elfiky , Mohammed Ali Farag |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة فيتوكيميائيه و بيولوجيه لبعض أنواع السدر التى تنمو فى مصر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Sarah Tareq Esmail Ali Sakna , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
263 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Genus Ziziphus (Rhamnaceae) is well characterized for its multi benefits aside from its fruit nutritive value, its leaf decoction is a common healthy beverage in many cultures. Albeit, no detailed metabolites characterization is reported for its leaf till now, with most research focused on its fruits. Here we have employed UHPLC/PDA/ESI-MS technique to characterize the secondary metabolites profile of three traditionally used Ziziphus leaf taxa including: Z. spina-christi, Z. mauritiana and Z. jujuba revealing the first full insight onto Ziziphus leaf metabolome. A total of 102 metabolites were characterized including several novel flavonoids and cyclopeptide alkaloids first time to be reported from the genus. Additionally, fragmentation pattern for cyclopeptide alkaloids was proposed via ESI-MS. Principal component analysis (PCA) revealed close metabolite resemblance among Z. spina-christi and Z. mauritiana leaf specimens found enriched in saponins and distinct from that of Z. jujuba in which quercetin-3-O-(2-pentosyl)-rhamnoside was most abundant. In-vitro antioxidant, Ü-glucosidase, COX-1 and tyrosinase inhibitory assays revealed for Z. spina-christi and Z. mauritiana strong effects compared to Z. jujuba and in correlation with their metabolites repertoire supporting their medicinal values. Isolation of 4 triterpenic acids, 1 flavonoid and 1 saponin was achieved from Z. mauritiana Lam. leaf revealed as one of the most active investigated species. Further, antidiabetic effectiveness of Z. mauritiana on streptozocin induced diabetic rats was also investigated |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Flavonoids |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
UHPLC-MS |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Ziziphus |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Marwan Marwan Shabana , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohammed Ali Farag , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nabaweya Mostafa Elfiky , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
