Screening azoreductase activity in human microbiota / (Record no. 74195)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02560cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190928s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.Ph.D.2019.Sa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sara Ahmed Zahran Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Screening azoreductase activity in human microbiota / |
| Statement of responsibility, etc. | Sara Ahmed Zahran Mohamed ; Supervised Ramy K. Aziz , Abdelgawad M. Hashem , Amal E. Ali |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مسح نشاط نزيم الازوريداكتيز للبكتيريا المتعايشة فى جسم الانسان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sara Ahmed Zahran Mohamed , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 201 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The gut microbiota enriches the human gene pool and contributes to xenobiotic metabolism. For example, microbial azoreductases modulate the reduction of azo-bonds, activating produgs and azo polymer-coated dosage forms, or degrading food additives. Here we aimed atinvestigating different aspects of azoreductases in the human gut microbiome by constructing a specialized refined database for azodye-degrading enzymes to explore their evolutionary relationships, functional sites and structural properties; and by mining public gut and skin metagenomic for novel enzyme variants sets using various bioinformatics tools. Our database represents a core set of which to add any new sequences coding for azodyes degrading enzymes showed the dominance of phyla gamma-Proteobacteria and Firmicutes as well as NADH-dependency. A color-coded similarity matrix of the database delineated two main clusters of structural similarity belonging to different bacterial spices. Phylogenetic analysis of the database sequences distinguished three main clusters, two of which entirely made up of different Proteobacteria subphyla while the third gathered up all azoreductases of Firmicutes and Mycoplasma. Inner clustering of the database reduced its size to nearly 25%;yet the dominance of gamma-Proteobacteria and Firmicutes was not affected |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Azoreductase |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | E. faecalis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gut microbiota |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelgawad M. Hashem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal E. Ali , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ramy K. Aziz , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.Ph.D.2019.Sa.S | 01010110079477000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.Ph.D.2019.Sa.S | 01020110079477000 | 22.09.2023 | CD - Rom | 79477.CD |