MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02683cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190901s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2019.Me.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Menna-t-Allah Assem Metwally |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Nanosized dosage forms as a tool for enhancing the solubility of a certain insoluble drug / |
| Statement of responsibility, etc. |
Menna-t Allah Assem Metwally ; Supervised Dalia Mahmoud Ghorab , Omneya Abdelkader |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الأشكال دقيقة الحجم كأداة لتحسين ذوبان عقار شحيح الذوبان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Menna Allah Assem Metwally , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
119 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The emergence of combinatorial chemistry and high throughput screening in drug development programs has led to a generation of molecules with poor aqueous solubility and poor bioavailability profile. In recent years, newly research about active chemical entity had increased steadily in the number, but most of them are insoluble in water. More than 40% of the candidate drugs have poor water solubility. Topical delivery of drugs directly into the skin offers a targeted approach for the treatment of dermatological conditions and other localized disease states.Various strategies have been investigated in order to overcome the skin permeability barrier, which is the stratum corneum. Nanocarriers used to enhance dermal and transdermal delivery are colloids including liposomes,cubosomes, solid lipid nanoparticles, nanostructured lipid carriers, nanocrystals and finally lipid and polymer-based micellar solutions. Beclomethasone dipropionate is a highly potent glucocorticoid receptor agonist that interacts either directly with the DNA or indirectly by modulating specific transcription factors, resulting in the modulation of protein synthesis. It acts by inhibiting phospholipase A₂ resulting in the inhibition of arachidonic acid synthesis and controlling prostaglandins and leukotriene synthesis eventually, leading to anti-inflammatory, immunosuppressive and the antiproliferative effect. It is practically insoluble in water with poor dermal bioavailability |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Beclomethasone dipropionate |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Mixed micelles |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nanocrystals |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dalia Mahmoud Ghorab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Omneya Abdelkader , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
