Synthesis and biological evaluation of some new nitrogen heterocyclic compounds / (Record no. 74258)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02270cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191001s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.04.Ph.D.2019.Is.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Islam Zaki Abdelazeem Abutaleb |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and biological evaluation of some new nitrogen heterocyclic compounds / |
| Statement of responsibility, etc. | Islam Zaki Abdelazeem Abutaleb ; Supervised Mohammed Kamal Abdelhameid , Khaled Omar Ahmed Mohamed , Ibrahim Elsayed Mohey Eldeen |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التشييد والتقييم البيولوجى لبعض المركبات النيتروجينية الغير متجانسة الجديدة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Islam Zaki Abdelazeem Abutaleb , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 183 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A new series of diamide, imidazolone, 1,2,4-triazole and 1,2,4-triazinone derivatives have been designed, synthesized starting from N-benzoylglycine derivatives. Structures of the synthesized compounds have been deduced on the basis of their spectroscopic methods and elemental analyses data. The in vitroantitumor activity of the newly synthesized compounds were screenedagainstHepG2 and MCF-7 cell lines. Cell cycle analysis were carried out for some of the prepared compounds and demonstrated cell cycle arrest at G1 or G2/M phases of cell cycle.Additionally, the compounds produced a significant reduction in cellular microtubules for microtubule loss and potently inhibited the binding of [3H]colchicine to tubulin. Finally, some of the prepared compounds were proved to upregulate expression of proteins triggering apoptosis such as p53, Bax and decreased Bcl-2 overexpression as well as increased the expression of effector caspase-3/7. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diamide |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Imidazolone |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxazolone |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ibrahim Elsayed Mohey Eldeen , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khaled Omar Ahmed Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Kamal Abdelhameid , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.04.Ph.D.2019.Is.S | 01010110079498000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.04.Ph.D.2019.Is.S | 01020110079498000 | 22.09.2023 | CD - Rom | 79498.CD |