The role of mannose binding lectin (MBL2) gene polymorphism in incidence of neonatal sepsis / (Record no. 74300)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02878cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032411.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191005s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.Ph.D.2019.Mo.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ahmed Abdeltawab |
| 245 14 - TITLE STATEMENT | |
| Title | The role of mannose binding lectin (MBL2) gene polymorphism in incidence of neonatal sepsis / |
| Statement of responsibility, etc. | Mohamed Ahmed Abdeltawab ; Supervised Ismail Mohamed Bahi Eldin Elhawary , Nouran Fahmy Hussain , Aliaa Adel Ali |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دور تعدد الأشكال الجيني لكتين ملزم المانوز فى الاطفال حديثي الولادة المصابين بمرض تسمم الدم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Ahmed Abdeltawab , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 151 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Mannose-binding lectin (MBL) is a component of innate immunity and is particularly important in neonates, in whom adaptive immunity has not yet completely developed. MBL deficiency and MBL2 gene polymorphisms are associated with an opsonization defect and have been associated with neonatal sepsis. Aim: The aim of this work was to assess the role of serum MBL level as a diagnostic value of neonatal sepsis and to assess the relation of MBL2 gene polymorphism at codon 54 (G/A) in the development of neonatal sepsis. Patients and Methods: A case-control study was conducted with 100 preterm neonates classified into two groups: the septic group included 50 neonates and the non-septic control group included 50 neonates. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to genotype MBL2 gene exon 1 (codon 54 (G/A), rs1800450) SNPs. Enzyme-linked immunosorbent assay (ELISA) was used to measure MBL serum concentrations. Results: Serum MBL was significantly lower in septic neonates than the controls (P<0.0001).The heteromutant (GA) genotype of codon 54 was significantly higher in septic neonates than controls (P=0.033). However, the homomutant (AA) genotype of codon 54 was higher in septic neonates than controls but the difference did not reach statistical significance (P=0.242). The abnormal A allele was significantly higher in septic neonates than controls (P=0.0025) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Codon 54 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gene polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mannose-binding lectin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aliaa Adel Ali , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Mohamed Bahi Eldin Elhawary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nouran Fahmy Hussain , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.Ph.D.2019.Mo.R | 01010110079503000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.Ph.D.2019.Mo.R | 01020110079503000 | 22.09.2023 | CD - Rom | 79503.CD |