MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02647cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
191005s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2019.Kh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kholoud Mamdouh Abdelfattah Mohamed |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A pharmaceutical study on in-situ gelling mucoadhesive formulations for rectal administration / |
| Statement of responsibility, etc. |
Kholoud Mamdouh Abdelfattah Mohamed ; Supervised Dalia Mahmoud Ghorab , Marwa H. Shukr |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة صيدلية علي تركيبات دوائية في صورة محلول هلامي موضعي ملاصق للمخاط بالمستقيم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Kholoud Mamdouh Abdelfattah Mohamed , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
186 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Chronic anal fissures (CAF) is a troubling and painful condition that affects a great majority of population. Its current clinical management options are either operative or non-operative treatment. Innovative prospects for non-operative medical treatment have been lately employed taking in consideration reduction of the internal anal sphincter (IAS) muscle tone. Phosphodiesterase inhibitors (PDEIs) have proven to cause a dose-dependent reduction in the tone of the internal anal sphincter muscle and promote wound healing. Dipyridamole (DP) as phosphodiesterase inhibitor was selected for topical rectal application in the treatment of anal fissures. As DP is a poorly soluble drug, enhancing its solubility represented a rate limiting step for its formulation.Therefore, microemulsion (ME) technique was used to provide a proper enhancement for DP solubilization. Dipyridamole ME formulations were loaded on to thermosensitive in-situ gel dosage form to facilitate rectal administration. Poloxamer 407 (P 407) was used as the thermosensitive polymer as it exhibits sol-gel transition at body temperature (37{u00B0}C).The prepared in-situ gel formulations were provided with mucoadhesive polymers as Sodium alginate (Na Alg.) and Hydroxypropyl methyl cellulose (HPMC) to prolong the residence time of the prepared formulation at the site of action |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Chronic anal fissures (CAF) |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
In-situ gelling mucoadhesive |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Rectal administration |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dalia Mahmoud Ghorab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Marwa H. Shukr , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
